IL-17A/lL-17RA reduces cisplatin sensitivity of ovarian cancer SKOV3 cells by regulating autophagy.
10.12122/j.issn.1673-4254.2020.11.03
- Author:
Lihua WANG
1
;
Xuan ZHANG
1
;
Liangliang WANG
1
;
Beibei WANG
1
;
Jing ZHANG
1
;
Yuzhi LI
1
Author Information
1. Department of Gynecology, First Affiliated Hospital of Bengbu Medical College, Bengbu 233004, China.
- Publication Type:Journal Article
- Keywords:
autophagy;
cisplatin;
drug resistance;
interleukin-17A;
ovarian cancer
- MeSH:
Antineoplastic Agents/therapeutic use*;
Apoptosis/drug effects*;
Autophagy/drug effects*;
Cell Line, Tumor;
Cell Proliferation/drug effects*;
Cisplatin/pharmacology*;
Drug Resistance, Neoplasm/drug effects*;
Female;
Humans;
Interleukin-17/pharmacology*;
Ovarian Neoplasms/drug therapy*;
Receptors, Interleukin-17
- From:
Journal of Southern Medical University
2020;40(11):1550-1556
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of interleukin-17A (IL-17A) on chemosensitivity of ovarian cancer cells to cisplatin (DDP) and explore the mechanism in light of autophagy regulation.
METHODS:Ovarian cancer SKOV3 cells cultured
RESULTS:DDP increased the expression of IL-17RA in ovarian cancer SKOV3 cells. Treatment with IL-17A significantly reduced the susceptibility of SKOV3 cells to cisplatin-induced apoptosis (
CONCLUSIONS:IL-17A/IL-17RA can decrease chemosensitivity of SKOV3 cells to DDP by upregulating DDP-induced autophagy.
