Escin alleviates chemotherapy-induced peripheral neuropathic pain by inducing autophagy in the spinal cord of rats.
10.12122/j.issn.1673-4254.2020.11.15
- Author:
Fang YAN
1
;
Dongtai CHEN
1
;
Jingdun XIE
1
;
Weian ZENG
1
;
Qiang LI
1
Author Information
1. Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou 510060, China.
- Publication Type:Journal Article
- Keywords:
LC3II;
chemotherapy;
escin;
p62;
peripheral neuropathic pain
- MeSH:
Animals;
Antineoplastic Agents/therapeutic use*;
Autophagy;
Escin/therapeutic use*;
Hyperalgesia/drug therapy*;
Mice;
Neuralgia/drug therapy*;
Rats;
Rats, Sprague-Dawley;
Spinal Cord
- From:
Journal of Southern Medical University
2020;40(11):1634-1638
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the effect of escin in relieving chemotherapy-induced peripheral neuropathic pain in rats and explore and the underlying mechanism.
METHODS:Eighteen SD rats were randomly divided into 3 groups (
RESULTS:The rats in both the escin preconditioning group and escin postconditioning group showed obviously increased thresholds of mechanical allodynia and thermal hyperalgesia as compared with those in the control group (
CONCLUSIONS:Escin can alleviate chemotherapy-induced peripheral neuropathic pain in rats possibly by upregulating the expressions of autophagy-related proteins in the spinal cord.
