Cardiac functional alterations and its risk factors in elderly patients with obstructive sleep apnea syndrome free of cardiovascular disease.
10.12122/j.issn.1673-4254.2020.11.08
- Author:
Yinghui GAO
1
;
Yongfei WEN
1
;
Xiaoshun QIAN
2
;
Libo ZHAO
3
;
Hu XU
3
;
Weihao XU
3
;
Xiaoxuan KONG
3
;
Hebin CHE
4
;
Yabin WANG
5
;
Lin LIU
2
Author Information
1. PKU-UPenn Sleep Center, Peking University International Hospital, Beijing 102206, China.
2. Department of Pulmonary and Critical Care Medicine, General Hospital of PLA, Beijing 100853, China.
3. Department of Geriatric Cardiology, Second Medical Center of General Hospital of PLA, Beijing 100853, China.
4. Big Data Center, General Hospital of PLA, Beijing 100853, China.
5. National Clinical Research Center for Geriatric Diseases, General Hospital of PLA, Beijing 100853, China.
- Publication Type:Journal Article
- Keywords:
apnea-hypopnea index;
cardiac diastolic function;
elderly;
obstructive sleep apnea
- MeSH:
Aged;
Cardiovascular Diseases/etiology*;
Humans;
Risk Factors;
Severity of Illness Index;
Sleep Apnea, Obstructive/complications*;
Stroke Volume;
Ventricular Dysfunction, Left;
Ventricular Function, Left
- From:
Journal of Southern Medical University
2020;40(11):1587-1592
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To evaluate the changes of cardiac structure and function and their risk factors in elderly patients with obstructive sleep apnea syndrome (OSA) without cardiovascular complications.
METHODS:Eighty-two elderly OSA patients without cardiovascular disease admitted between January, 2015 and October, 2016 were enrolled in this study. According to their apnea-hypopnea index (AHI, calculated as the average number of episodes of apnoea and hypopnoea per hour of sleep), the patients were divided into mild OSA group (AHI < 15) and moderate to severe OSA group (AHI ≥ 15). The demographic data and the general clinical data were recorded and fasting blood samples were collected from the patients on the next morning following polysomnographic monitoring for blood cell analysis and biochemical examination. Echocardiography was performed within one week after overnight polysomnography, and the cardiac structure, cardiac function and biochemical indexes were compared between the two groups.
RESULTS:Compared with those with mild OSA group, the patients with moderate to severe OSA had significantly higher hematocrit (0.22±0.08
CONCLUSIONS:Cardiac diastolic function impairment may occur in elderly patients with moderate or severe OSA who do not have hypertension or other cardiovascular diseases, and the severity of the impairment is positively correlated with AHI.
