Arctiin antagonizes triptolide-induced renal toxicity in rats via anti-inflammatory pathway.
10.12122/j.issn.1673-4254.2020.10.04
- Author:
Yuyan ZHOU
1
;
Xiaoya LU
1
;
Li XIA
1
;
Weiqiang YAO
1
;
Guozheng QIN
1
;
Guodong WANG
1
Author Information
1. Drug Research and Development Center//School of Pharmacy, Wannan Medical College, Wuhu 241002, China.
- Publication Type:Journal Article
- Keywords:
anti-inflammatory pathway;
arctiin;
renal injury;
triptolide
- MeSH:
Animals;
Anti-Inflammatory Agents;
Diterpenes/toxicity*;
Epoxy Compounds/toxicity*;
Furans;
Glucosides;
Kidney/drug effects*;
Phenanthrenes/toxicity*;
Rats;
Rats, Sprague-Dawley
- From:
Journal of Southern Medical University
2020;40(10):1399-1405
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the protective effect of arctiin with anti-inflammatory bioactivity against triptolide-induced nephrotoxicity in rats and explore the underlying mechanism.
METHODS:Forty SD rats were divided into 4 groups for gastric lavage of normal saline, arctiin (500 mg/kg), triptolide (500 μg/kg), or both arctiin (500 mg/kg) and triptolide (500 μg/kg). Blood samples were collected for analysis of biochemical renal parameters, and the renal tissues were harvested for determining the kidney index and for pathological evaluation with HE staining. In the
RESULTS:In SD rats, arctiin significantly antagonized triptolide-induced elevation of BUN, Scr and kidney index (
CONCLUSIONS:Arctiin can protect the kidney from triptolide-induced damages in rats possibly through the anti-inflammatory pathway.
