Correlation of type 2 diabetes and impaired glucose regulation with chronic kidney disease in middle-aged and elderly individuals.
10.12122/j.issn.1673-4254.2020.10.11
- Author:
Qiangmei WANG
1
;
Jieyu ZHEN
2
;
Conghui GUAN
3
;
Nan ZHAO
3
;
Jinjin LIU
3
;
Hongli LI
3
;
Songbo FU
3
;
Xulei TANG
3
;
Yanping HAN
1
;
Shan SU
1
;
Di ZHANG
3
;
Lijuan LIU
1
;
Donghu ZHEN
3
Author Information
1. First College of Clinical Medicine, Lanzhou University, Gansu Provincial People's Hospital, Lanzhou 730000, China.
2. Department of Gynecology, Gansu Provincial People's Hospital, Lanzhou 730000, China.
3. Department of Endocrinology, First Hospital of Lanzhou University, Gansu Provincial People's Hospital, Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
albuminuria;
chronic kidney disease;
glucose metabolism;
middle-aged and elderly individuals
- MeSH:
Adult;
Aged;
Albuminuria/epidemiology*;
Diabetes Mellitus, Type 2/epidemiology*;
Female;
Glomerular Filtration Rate;
Glucose;
Humans;
Middle Aged;
Prevalence;
Renal Insufficiency, Chronic/epidemiology*;
Risk Factors
- From:
Journal of Southern Medical University
2020;40(10):1457-1464
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the correlation of different glucose metabolism statues with chronic kidney disease (CKD) in middle-aged and elderly individuals in Lanzhou.
METHODS:Based on the baseline data of REACTION Study in Lanzhou area, we randomly sampled 10 038 residents aged 40-75 years in 3 communities in Lanzhou, who were classified into normal glucose tolerance (NGT), impaired glucose regulation (IGR) and diabetes groups. The estimated glomerular filtration rate (eGFR) and urinary albumin-to-creatinine ratio (ACR) were used to assess the renal function and albuminuria, respectively. Binary logistic regression was performed to analyze the contribution of the risk factors to CKD. Polynominal regression was used to determine the trends of eGFR with the increment of ACR.
RESULTS:Among all the participants, the prevalences of albuminuria, CKD and renal insufficiency (RI) were 26.2%, 27.4% and 2.5%, respectively. The prevalence of albuminuria, CKD and RI were significantly higher in the diabetes group than in IGR and NGT groups (
CONCLUSIONS:Diabetes mellitus is a significant risk factor for albuminuria and RI, while IGR is not. Screening for albuminuria and eGFR is highly recommended for individuals with diabetes, hypertension, and obesity, especially in women and the elderly population.
