Esophageal pH-impedance monitoring of reflux patterns in non-erosive reflux disease, reflux hypersensitivity and functional heartburn.
10.12122/j.issn.1673-4254.2020.10.18
- Author:
Ajing ZHANG
1
;
Wenzhu YAO
2
;
Jia DI
3
;
Manli CUI
1
;
Mingxin ZHANG
1
;
Jun ZHANG
3
Author Information
1. First Affiliated Hospital of Xi'an Medical College, Xi'an 710077, China.
2. Xi'an Medical University, Xi'an 710032, China.
3. Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710003, China.
- Publication Type:Journal Article
- Keywords:
24-hour pH-impedance monitoring;
functional heartburn;
non-erosive esophagus reflux disease;
reflux hypersensitivity
- MeSH:
Electric Impedance;
Esophageal pH Monitoring;
Gastroesophageal Reflux/diagnosis*;
Heartburn/etiology*;
Humans;
Hydrogen-Ion Concentration
- From:
Journal of Southern Medical University
2020;40(10):1507-1512
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the differences in reflux patterns in 24-hour esophageal pH-impedance monitoring in patients with non-erosive reflux disease (NERD), reflux hypersensitivity (RH) and functional heartburn (FH) and explore the possible mechanism of symptoms in patients with heartburn and negative endoscopic findings.
METHODS:Seventy-nine patients with heartburn as the main symptoms but negative endoscopic findings, including 35 with NERD, 16 with RH and 28 with FH, were enrolled in this study.All the patients underwent 24-h esophageal pH-impedance monitoring and esophagogastroscopy, and the results were compared among the 3 groups.
RESULTS:Acid reflux episode was significantly increased and weakly alkaline reflux episode was significantly decreased in NERD group in comparison with RH group and FH group (
CONCLUSIONS:Patients with NERD, RH and FH had different reflux patterns.Acid reflux is predominant in the NERD, while weakly alkaline reflux is significantly increased RH and FH.In patients with normal esophageal acid exposure but without symptoms or without recorded symptoms during esophageal pH-impedance monitoring, analysis of the total reflux episode, mixed reflux episode, proximal acid reflux episode and percentage can help in the differential diagnosis between RH and FH.
