Exosomes in bladder cancer: novel biomarkers and targets.

Hao Geng; Qingchen Zhou; Wenhao Guo; Ling LU; Liangkuan BI; Yi Wang; Jie Min; Dexin YU; Zhaofeng Liang

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Exosomes in bladder cancer: novel biomarkers and targets.

Author: Hao GENG ¹ ; Qingchen ZHOU ² ; Wenhao GUO ³ ; Ling LU ⁴ ; Liangkuan BI ¹ ; Yi WANG ¹ ; Jie MIN ¹ ; Dexin YU ⁵ ; Zhaofeng LIANG ⁶
Author Information

1. Department of Urology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230032, China.
2. Department of Urology, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China.
3. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China.
4. Department of Child Healthcare, Women and Children Health Hospital of Zhenjiang, Zhenjiang 212001, China.
5. Department of Urology, the Second Affiliated Hospital of Anhui Medical University, Hefei 230032, China. dxyu@ahmu.edu.cn.
6. Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China. liangzhaofeng@ujs.edu.cn.
Publication Type:Journal Article
Keywords: Biomarker; Bladder cancer; Clinical application; Exosome; Function
From: Journal of Zhejiang University. Science. B 2021;22(5):341-347
CountryChina
Language:English
Abstract: Exosomes are nanometer-sized vesicles that contain various types of biologically active components, including proteins, nucleic acids, carbohydrates, and lipids, which vary with the type and physiological state of the cell. In recent years, several studies have showed that exosomes can provide new non-invasive diagnostic and prognostic biomarkers in patients affected by cancers, including bladder cancer (BC), and the lipid bilayer membrane structure makes exosomes as promising delivery vehicles for therapeutic applications. Exosomes have the characteristics of high abundance, high stability, tissue specificity, and wide distribution in body fluids, and are secreted as various types by cells in different states, thereby possessing great potential as biomarkers for BC. Herein, we briefly summarize the functions and roles of exosomes in the occurrence and development of BC and the current progress of research on exosomes in BC, while focusing on potential clinical applications of the diagnosis, treatment, and prognosis of BC.