Factors associated with a SARS-CoV-2 recurrence after hospital discharge among patients with COVID-19: systematic review and meta-analysis.
- Author:
Meng-Qi YAO
1
;
Qiu-Xian ZHENG
2
;
Jia XU
2
;
Jing-Wen DENG
2
;
Tian-Tian GE
2
;
Hai-Bo ZHOU
2
;
Feng-Tian WU
2
;
Xin-Yu GU
2
;
Qin YANG
2
;
Yan-Li REN
2
;
Gang WANG
2
;
Zhi CHEN
2
Author Information
- Publication Type:Systematic Review
- Keywords: Recurrence case; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); Risk factor; Meta-analysis
- MeSH: Age Factors; Blood Cell Count; CD4 Lymphocyte Count; COVID-19/pathology*; Cough; Dizziness; Headache; Humans; Patient Discharge; Recurrence; Risk Factors
- From: Journal of Zhejiang University. Science. B 2020;21(12):940-947
- CountryChina
- Language:English
-
Abstract:
BACKGROUND:The proportion of recurrences after discharge among patients with coronavirus disease 2019 (COVID-19) was reported to be between 9.1% and 31.0%. Little is known about this issue, however, so we performed a meta-analysis to summarize the demographical, clinical, and laboratorial characteristics of non-recurrence and recurrence groups.
METHODS:Comprehensive searches were conducted using eight electronic databases. Data regarding the demographic, clinical, and laboratorial characteristics of both recurrence and non-recurrence groups were extracted, and quantitative and qualitative analyses were conducted.
RESULTS:Ten studies involving 2071 COVID-19 cases were included in this analysis. The proportion of recurrence cases involving patients with COVID-19 was 17.65% (between 12.38% and 25.16%) while older patients were more likely to experience recurrence (weighted mean difference (WMD)=1.67, range between 0.08 and 3.26). The time from discharge to recurrence was 13.38 d (between 12.08 and 14.69 d). Patients were categorized as having moderate severity (odds ratio (OR)=2.69, range between 1.30 and 5.58), while those with clinical symptoms including cough (OR=5.52, range between 3.18 and 9.60), sputum production (OR=5.10, range between 2.60 and 9.97), headache (OR=3.57, range between 1.36 and 9.35), and dizziness (OR=3.17, range between 1.12 and 8.96) were more likely to be associated with recurrence. Patients presenting with bilateral pulmonary infiltration and decreased leucocyte, platelet, and CD4
CONCLUSIONS:The main factors associated with the recurrence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) after hospital discharge were older age, moderate severity, bilateral pulmonary infiltration, laboratory findings including decreased leucocytes, platelets, and CD4
