Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus.

Bo Zhu; Zhixin MA; Yuning Zhu; Lei Fang; Hong Zhang; Hongwei Kong; Dajing Xia

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Reduced glycodeoxycholic acid levels are associated with negative clinical outcomes of gestational diabetes mellitus.

Author: Bo ZHU ¹ ; Zhixin MA ¹ ; Yuning ZHU ¹ ; Lei FANG ¹ ; Hong ZHANG ¹ ; Hongwei KONG ² ; Dajing XIA ³
Author Information

1. Department of Laboratorial Medicine, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
2. Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
3. Department of Toxicology, School of Public Health, Zhejiang University, Hangzhou 310006, China. dxia@zju.edu.cn.
Publication Type:Journal Article
Keywords: Bile acid; Gestational diabetes mellitus (GDM); Insulin resistance; β-Cell compensation
From: Journal of Zhejiang University. Science. B 2021;22(3):223-232
CountryChina
Language:English
Abstract: Gestational diabetes mellitus (GDM) is characterized by glycemia and insulin disorders. Bile acids (BAs) have emerged as vital signaling molecules in glucose metabolic regulation. BA change in GDM is still unclear, which exerts great significance to illustrate the change of BAs in GDM. GDM patients and normal pregnant women were enrolled during the oral glucose tolerance test (OGTT) screening period. Fasting serums were sampled for the measurement of BAs. BA metabolism profiles were analyzed in both pregnant women with GDM and those with normal glucose tolerance (NGT). Delivery characteristics, delivery gestational age, and infant birthweight were extracted from medical records. GDM patients presented distinctive features compared with NGT patients, including higher body mass index (BMI), elevated serum glucose concentration, raised insulin (both fasting and OGTT), and increased hemoglobin A1c (HbA1c) levels. Higher homeostasis model assessment of insulin resistance (HOMA-IR) and decreased β-cell compensation (i.e., oral disposition index (DI