Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics.

Wenjing Huang; Shenglin Luo; Dong Yang; Sheng Zhang

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Applications of smartphone-based near-infrared (NIR) imaging, measurement, and spectroscopy technologies to point-of-care (POC) diagnostics.

Author: Wenjing HUANG ¹ ; Shenglin LUO ² ; Dong YANG ³ ; Sheng ZHANG ⁴
Author Information

1. Ningbo Research Institute, Zhejiang University, Ningbo 315100, China.
2. Institute of Combined Injury, State Key Laboratory of Trauma, Burn and Combined Injury, College of Preventive Medicine, Third Military Medical University, Chongqing 400038, China.
3. Division of Biomedical Engineering, Renal Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge 02139, USA.
4. Ningbo Research Institute, Zhejiang University, Ningbo 315100, China. szhang1984@nit.zju.edu.cn.
Publication Type:Journal Article
Keywords: Aggregation-induced emission (AIE); Fluorescent probe; Near-infrared (NIR) fluorescent imaging; Point-of-care (POC) diagnostics; Smartphone-based imaging
From: Journal of Zhejiang University. Science. B 2021;22(3):171-189
CountryChina
Language:English
Abstract: The role of point-of-care (POC) diagnostics is important in public health. With the support of smartphones, POC diagnostic technologies can be greatly improved. This opportunity has arisen from not only the large number and fast spread of cell-phones across the world but also their improved imaging/diagnostic functions. As a tool, the smartphone is regarded as part of a compact, portable, and low-cost system for real-time POC, even in areas with few resources. By combining near-infrared (NIR) imaging, measurement, and spectroscopy techniques, pathogens can be detected with high sensitivity. The whole process is rapid, accurate, and low-cost, and will set the future trend for POC diagnostics. In this review, the development of smartphone-based NIR fluorescent imaging technology was described, and the quality and potential of POC applications were discussed.