High expression of FABP4 in colorectal cancer and its clinical significance.

Yan Zhang; Wenjia Zhang; Min Xia; Zhujun Xie; Fangmei AN; Qiang Zhan; Wenying Tian; Tianyue Zhu

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High expression of FABP4 in colorectal cancer and its clinical significance.

Author: Yan ZHANG ¹ ; Wenjia ZHANG ² ; Min XIA ³ ; Zhujun XIE ² ; Fangmei AN ² ; Qiang ZHAN ² ; Wenying TIAN ² ; Tianyue ZHU ²
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1. Department of Gastroenterology, the Second Affiliated Hospital of Nantong University, Nantong 226001, China.
2. Department of Gastroenterology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China.
3. Department of Gastroenterology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi 214023, China. xmzb1013@163.com.
Publication Type:Journal Article
Keywords: Colorectal cancer (CRC); Epithelial-mesenchymal transition; Fatty acid-binding protein 4 (FABP4)
From: Journal of Zhejiang University. Science. B 2021;22(2):136-145
CountryChina
Language:English
Abstract: OBJECTIVES:To investigate the relationship between the fatty acid-binding protein 4 (FABP4) and colorectal cancer (CRC).
METHODS:Using an enzyme-linked immunosorbent assay (ELISA), we measured the expression of FABP4 in plasma of 50 patients who underwent surgery for CRC from October 2017 to May 2018 and 50 healthy controls. The content of the visceral fat area (VFA) as seen with abdominal computed tomography (CT) scanning was measured by ImageJ software. The expression levels of FABP4, E-cadherin, and Snail proteins in CRC and adjacent tissues were determined by immunohistochemistry.
RESULTS:The mean concentration of plasma FABP4 of CRC patients was higher than that of the control group (22.46 vs. 9.82 ng/mL;
CONCLUSIONS:High LPA and VFA were risk factors for increased plasma FABP4 in CRC patients. FABP4 protein was highly expressed in CRC tissues and associated with TNM stage, differentiation, and lymph node metastasis of CRC. The level of FABP4 in CRC tissue was correlated with E-cadherin and Snail expression, suggesting that FABP4 may promote CRC progression related to epithelial-mesenchymal transition (EMT).