Genome instability and lymphoma.
10.11817/j.issn.1672-7347.2021.190427
- Author:
Pengfei CAO
1
;
Guiyuan LI
2
;
Juanjuan XIANG
3
Author Information
1. Department of Hematology, Xiangya Hospital, Central South University, Changsha 410008. caopengfei66@163.com.
2. Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha 410078, China. lgy@csu.edu.cn.
3. Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- Keywords:
chromosomal instability;
genome instability;
lymphoma;
microsatellite instability
- MeSH:
Genomic Instability;
Humans;
Lymphoma/genetics*;
Microsatellite Instability;
Microsatellite Repeats;
Neoplasms
- From:
Journal of Central South University(Medical Sciences)
2021;46(5):552-557
- CountryChina
- Language:English
-
Abstract:
Lymphoma is one of the most common malignant tumor of the hematologic system. The genome instability is not only an important molecular basis for the development of lymphoma, but also has important value in the diagnosis and prognosis of lymphoma. There are 2 types of genome instability: Microsatellite instability (MSI/MIN) at gene level and chromosomal instability at chromosome level. Through the study on genes associated with lymphoma, the unstable genes associated with lymphoma could be found, meanwhile the mechanism of its occurrence and development of lymphoma could be explored, and the important basis of molecular biology could also be provided in the field of current hot lymphoma precision medical research.
