RNA methylation and neurovascular unit remodeling.
10.11817/j.issn.1672-7347.2021.200246
- Author:
Xinyi LÜ
1
;
Yishu FAN
2
;
Shuntong KANG
2
;
Bo XIAO
2
;
Mengqi ZHANG
3
Author Information
1. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. lvxinyi1368@163.com.
2. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China.
3. Department of Neurology, Xiangya Hospital, Central South University, Changsha 410008, China. zhangmengqi8912@163.com.
- Publication Type:Journal Article
- Keywords:
5-methylcytosine;
N6-methyladenosine;
RNA methylation;
blood vessel;
neuron;
neurovascular unit
- MeSH:
5-Methylcytosine;
Adenosine/metabolism*;
Methylation;
Methyltransferases/metabolism*;
RNA
- From:
Journal of Central South University(Medical Sciences)
2021;46(5):536-544
- CountryChina
- Language:English
-
Abstract:
RNA methylation is of great significance in the regulation of gene expression, among which the more important methylation modifiers are N6-methyladenosine (m6A) and 5-methylcytosine (m5C). The methylation process is mainly regulated by 3 kinds of proteins: methyltransferase, demethylase, and reader. m6A, m5C, and their related proteins have high abundance in the brain, and they have important roles in the development of the nervous system and the repair and remodeling of the vascular system. The neurovascular unit (NVU) is a unit of brain structure and function composed of neurons, capillaries, astrocytes, supporting cells, and extracellular matrix. The local microenvironment for NVU has an important role in nerve cell function repair, and the remodeling of NVU is of great significance in the prognosis of various neurological diseases.
