Association between single nucleotide polymorphisms of tropoelastin gene and aortic dissection.
10.11817/j.issn.1672-7347.2021.200624
- Author:
Youfei QI
1
;
Chang SHU
2
;
Sahua LIU
3
;
Hao CHEN
3
;
Wenbo ZHANG
3
Author Information
1. Department of Vascular Surgery, Hainan General Hospital, Haikou 570311. qiyoufei@aliyun.com.
2. Department of Vascular Surgery, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Vascular Surgery, Hainan General Hospital, Haikou 570311.
- Publication Type:Journal Article
- Keywords:
aortic dissection;
elastin;
haplotype;
single nucleotide polymorphisms;
tropoelastin gene
- MeSH:
Aneurysm, Dissecting/genetics*;
Elastic Tissue;
Elastin/genetics*;
Humans;
Polymorphism, Single Nucleotide;
Tropoelastin/genetics*
- From:
Journal of Central South University(Medical Sciences)
2021;46(5):458-466
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To evaluate the relation between single nucleotide polymorphisms (SNPs) of tropoelastin gene and aortic dissection (AD) via identifying SNPs in the tropoelastin gene, and to detect the level of tropoelastin mRNA, elastin and elastic fibers.
METHODS:The specimens of the AD group (
RESULTS:Seven SNP loci of the tropoelastin gene were detected in these samples. Among them, 5 SNP loci were polymorphic. The frequency of 3 SNP loci[rs2071307 (G/A), rs34945509 (C/T) and rs17855988 (G/C)] was significantly different between the AD group and the control group (all
CONCLUSIONS:The polymorphisms of rs2071307 (G/A), rs34945509 (C/T), and rs17855988(G/C) in the tropoelastin gene may eventually affect the synthesis of elastic fibers and they may play an important role in the occurrence of AD.
