Animal models for study on rotator cuff injury.
10.11817/j.issn.1672-7347.2021.200064
- Author:
Ping LIU
1
;
Weihong ZHU
2
;
Qian LIU
3
Author Information
1. Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China. 923287609@qq.com.
2. Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China.
3. Department of Orthopaedics, Second Xiangya Hospital, Central South University, Changsha 410011, China. liuqian825@hotmail.com.
- Publication Type:Journal Article
- Keywords:
animal model;
rotator cuff injury;
tendon to bone healing
- MeSH:
Animals;
Cattle;
Disease Models, Animal;
Dogs;
Mice;
Rabbits;
Rats;
Rotator Cuff;
Rotator Cuff Injuries;
Sheep;
Tendon Injuries;
Wound Healing
- From:
Journal of Central South University(Medical Sciences)
2021;46(4):426-431
- CountryChina
- Language:English
-
Abstract:
Rotator cuff injuries are the most common cause of shoulder pain and dysfunction. Ideal animal shoulder models should have similar shoulder anatomy and function as human, and are able to replicate the microenvironment change after tendon injury. At present, a variety of animal models including rat, mouse, rabbit, sheep, canine, bovine, and primate have been used to study the mechanism of rotator cuff injury, effects of different repair techniques, and factors affecting tendon to bone healing. Although large animal models are more anatomically similar to humans, small animal models are more convenient in revealing the biological mechanism of rotator cuff injury and healing. Choosing appropriate animal models based on research objectives and establishing new small animal models play a critical role in revealing the mechanism of rotator cuff diseases and developing novel treating strategies.
