Effect of the infusion ration between frozen plasma and plasma substitutes on the prognosis of adult patients with major burn in shock stage.
10.11817/j.issn.1672-7347.2021.190565
- Author:
Kun XIAO
1
;
Fei ZHAO
2
;
Jiangbo WAN
3
;
Aiping LE
4
Author Information
1. Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006. 376069793@qq.com.
2. Department of Neurology, First Affiliated Hospital of Nanchang University, Nanchang 330006.
3. Department of Burn, First Affiliated Hospital of Nanchang University, Nanchang 330006, China.
4. Department of Blood Transfusion, First Affiliated Hospital of Nanchang University, Nanchang 330006. leaiping@126.com.
- Publication Type:Journal Article
- Keywords:
30-day mortality;
frozen plasma;
infusion ration;
major burn;
prognosis
- MeSH:
Adult;
Hospitalization;
Humans;
Plasma Substitutes;
Prognosis;
Retrospective Studies;
Shock
- From:
Journal of Central South University(Medical Sciences)
2021;46(4):393-399
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:In recent years, it has been reported that the anti-shock effect of plasma substitutes in adult patients with major burn in shock stage is not good. However, due to the shortage of clinical frozen plasma supply, it is impossible to guarantee that frozen plasma is used as colloidal solution for anti-shock treatment. The purpose of this study is to explore the effect of the infusion ration between frozen plasma and plasma substitutes on the prognosis of adult patients with major burn in shock stage.
METHODS:This study enrolled 586 adult patients with major burn by selecting the hospitalization burn patients, who had been hospitalized at the Jiangxi province burn center from September 2014 to April 2019. The patients with the infusion ratio of frozen plasma to plasma substitutes ≥2꞉1 at 48 hours after admission were included in the experimental group, otherwise they were included in the control group. The basic clinical data and clinical prognosis indicator in the 2 groups were compared. Logistic univariate regression analysis was used to screen the influential factors of 30-day mortality in adult patients with major burn, and logistic multivariate regression analysis was used to obtain independent risk and protective factors; Kaplan-Meier method was used to draw the survival curve of the 2 groups, and log-rank test was used to compare the 30-day survival rate of the 2 groups.
RESULTS:There were significant differences in the infusion volume of frozen plasma and plasma substitutes between the 2 groups at 48 hours after admission (both
CONCLUSIONS:Infusion ration between frozen plasma to plasma substitutes at 48 hours after admission is an independent protective factor for 30-day mortality of adult patients with major burn. In the early stage of adult patients with major burn, frozen plasma should be used as the anti-shock therapy as far as possible (frozen plasma꞉plasma substitute ≥2꞉1) to improve the prognosis and reduce the of 30-day mortality.
