HIF
10.11817/j.issn.1672-7347.2021.200010
- Author:
Wen TANG
1
;
Tingting LONG
2
;
Fangfang LI
2
;
Cong PENG
2
;
Shuang ZHAO
2
;
Xiang CHEN
2
;
Juan SU
3
Author Information
1. Department of Geriatrics, Xiangya Hospital, Central South University, Changsha 410008. 465743753@qq.com.
2. Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha 410008.
3. Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University, Changsha 410008. sujuanderm@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
CD147;
glucose transporter 1;
glycolysis;
hypoxia-inducible factor-1α;
psoriasis
- MeSH:
Basigin;
Glucose Transporter Type 1;
Glycolysis;
Humans;
Hypoxia-Inducible Factor 1, alpha Subunit/genetics*;
Psoriasis/genetics*;
Transcriptional Activation;
Up-Regulation
- From:
Journal of Central South University(Medical Sciences)
2021;46(4):333-344
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To analyze the expressions and distributions of hypoxia-inducible factor-1α (HIF-1α), CD147, and glucose transporter 1 (GLUT1) in epidermis from psoriasis vulgaris and normal people, and to explore the associations among these proteins and their roles in hypoxic HaCaT cell line.
METHODS:The expression levels of HIF-1α, CD147, and GLUT1 were determined by immunohistochemistry staining in skin biopsies from 48 psoriasis vularis patients and 33 healthy subjects. Cobalt chloride (CoCl
RESULTS:HIF-1α, CD147, and GLUT1 were highly expressed and the glycolytic capacity was increased in lesions of psoriasis vulgaris; HIF-1α upregulated the expression of CD147 and GLUT1, increased the lactate production and decreased the ATP level in CoCl
CONCLUSIONS:Glycolytic capacity increases in the injured keratinocytes of psoriasis vulgaris, suggesting that HIF-1α, CD147, and GLUT1 are associated with glycolysis, which can be considered as the promising targets for psoriasis therapy.
