Effect of exosome
10.11817/j.issn.1672-7347.2021.190702
- Author:
Yun WU
1
;
Jinfang LIU
2
Author Information
1. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China. 2354574316@qq.com.
2. Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha 410008, China. jinfang_liu@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
exosomes;
non-coding RNA;
traumatic brain injury
- MeSH:
Brain Injuries, Traumatic/genetics*;
Cell Communication;
Exosomes/genetics*;
Extracellular Vesicles;
Humans;
RNA, Untranslated/genetics*
- From:
Journal of Central South University(Medical Sciences)
2021;46(2):183-188
- CountryChina
- Language:English
-
Abstract:
Traumatic brain injury (TBI) is a main cause of death and disability worldwide, posing a serious threat to public health. But currently, the diagnosis and treatments for TBI are still very limited. Exosomes are a group of extracellular vesicles and participate in multiple physiological processes including intercellular communication and substance transport. Non-coding RNAs (ncRNA) are of great abundancy as cargo of exosomes. Previous studies have shown that ncRNAs are involved in several pathophysiological processes of TBI. However, the concrete mechanisms involved in the effects induced by exosome-derived ncRNA remain largely unknown. As an important component of exosomes, ncRNA is of great significance for diagnosis, precise treatment, response evaluation, prognosis prediction, and complication management after TBI.
