Effect of adverse childhood experiences and DNA methylation on male sexual orientation.
10.11817/j.issn.1672-7347.2021.190280
- Author:
Hanlin FU
1
;
Tubao YANG
2
;
Tingting WANG
2
;
Xiaobing WU
3
;
Nan XIA
3
;
Tiejian FENG
4
Author Information
1. Shenzhen Center for Chronic Disease Control, Shenzhen Guangdong 518020. 694400861@qq.com.
2. Xiangya School of Public Health, Central South University, Changsha 410078, China.
3. Shenzhen Center for Chronic Disease Control, Shenzhen Guangdong 518020.
4. Shenzhen Center for Chronic Disease Control, Shenzhen Guangdong 518020. fengtiej@126.com.
- Publication Type:Journal Article
- Keywords:
DNA methylation;
adverse childhood experiences;
male sexual orientation;
mechanism
- MeSH:
Adverse Childhood Experiences;
Child;
DNA Methylation;
Female;
Humans;
Male;
Sexual Behavior
- From:
Journal of Central South University(Medical Sciences)
2021;46(1):91-97
- CountryChina
- Language:English
-
Abstract:
The causes for male sexual orientation are complicated, which have not yet been clarified. Recent years have witnessed fruitful progress in the field of biology, while the impact of environment has received little attention. Adverse childhood experiences (ACEs), identified as a special environment in the early stage of development, can affect the individual phenotype by DNA methylation. Given the relationships among male sexual orientation, ACEs, and DNA methylation, as well as based on the existing theory, this article proposes the model "ACEs-DNA methylation-male sexual orientation"from the perspective of environment and epigenetics, aiming to provide a theoretical basis for future research.
