Mechanism of the Notch signaling pathway in enhancing the efficacy of chemotherapy drugs in osteosarcoma.
10.11817/j.issn.1672-7347.2020.190147
- Author:
Yichang SONG
1
Author Information
1. Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha 410011, China. gksychang@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Notch signaling pathway;
chemotherapy;
multidrug resistance;
osteosarcoma
- MeSH:
Bone Neoplasms/drug therapy*;
Cell Line, Tumor;
Cell Proliferation;
Humans;
Osteosarcoma/drug therapy*;
Pharmaceutical Preparations;
Receptors, Notch/genetics*;
Signal Transduction
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1234-1240
- CountryChina
- Language:English
-
Abstract:
Osteosarcoma is the most common malignant tumors of bone. Since 1970s, researchers had used chemotherapy drugs to treat osteosarcoma. However, multidrug resistance is a major adverse reaction that affects the efficacy of chemotherapy drugs, leading to the reduced survival rate of osteosarcoma patients. The Notch signaling pathway plays an important role in osteosarcoma proliferation, which affects tumor resistance by reducing intracellular drug accumulation, regulating epithelial-mesenchymal transition, dysregulating microRNA, disrupting the expression of apoptosis genes, and regulating tumor stem cells.
