Research progress in building and applying cardiomyocytes injury model.
10.11817/j.issn.1672-7347.2020.180737
- Author:
Jinhua ZHANG
1
;
Jun GUO
2
Author Information
1. Department of Cardiology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. zhangjinhua2018@163.com.
2. Department of Cardiology, First Affiliated Hospital of Jinan University, Guangzhou 510630, China. dr.guojun@163.com.
- Publication Type:Journal Article
- Keywords:
application;
cardiomyocytes injury model;
preparation
- MeSH:
Animals;
Cell Hypoxia;
Myocardial Reperfusion Injury/metabolism*;
Myocardium;
Myocytes, Cardiac/metabolism*;
Rats;
Rats, Sprague-Dawley;
Research
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1223-1227
- CountryChina
- Language:English
-
Abstract:
Cardiomyocytes injury model has been widely used in the study for the molecular mechanism of cardiovascular diseases and drug action. It is very important to select the appropriate model due to the different formation mechanisms for various models. Clinical cardiovascular pathological change is relatively complex. Currently used models according to the characteristics of clinical cardiovascular diseases mainly include hydrogen peroxide-induced myocardial cell damage model, hypoxia reoxygenation injury model, adriamycin-induced myocardial cell damage model, high sugar high fat-induced myocardial cell damage model, and isoprenaline-induced myocardial cell damage model. Every model has its advantages as well as its disadvantages. The suitable model of myocardial cell injury can be selected according to the research purpose.
