Clinical efficacy of Danhong injection in preventing contrast-induced acute kidney injury based on propensity score matching method.
10.11817/j.issn.1672-7347.2020.190191
- Author:
Jianglin WANG
1
;
Lingyun ZHOU
2
;
Wenjun YIN
2
;
Daiyang LI
2
;
Can HU
2
;
Xiaocong ZUO
3
Author Information
1. Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013. jianglin_wang@163.com.
2. Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013.
3. Department of Pharmacy, Third Xiangya Hospital, Central South University, Changsha 410013. zuoxc08@126.com.
- Publication Type:Journal Article
- Keywords:
Danhong injection;
acute kidney injury;
contrast agent;
propensity score matching method
- MeSH:
Acute Kidney Injury/prevention & control*;
Contrast Media/adverse effects*;
Drugs, Chinese Herbal;
Humans;
Injections;
Percutaneous Coronary Intervention;
Propensity Score;
Risk Factors;
Treatment Outcome
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1193-1198
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:Contrast-induced acute kidney injury (CI-AKI) is the third cause of hospital-acquired AKI, and existing clinical prevention and treatment measures such as hydration therapy and/or administration of antioxidants N-acetylcysteine treatment and other treatments still show little effect on the prevention and treatment of CI-AKI. This study aims to explore the effect of Danhong injection on prevention of CI-AKI.
METHODS:A total of 12 867 patients, who received coronary angiography, percutaneous coronary intervention, enhanced CT or vascular intervention in a tertiary hospital, were enrolled for this study. Among them, 423 in the treatment group received intravenous drip of Danhong injection, and 12 444 in the control group received routine medicine. Propensity score matching was conducted to balance confounding factors between the 2 groups and then the prevention effect of Danhong injection on CI-AKI was compared between them.
RESULTS:A total of 423 pairs of patients were matched successfully. The incidence of CI-AKI in the non-Danhong control group was higher than that in the Danhong treatment group (5.7% vs 2.4%). The difference between the 2 groups was statistically significant (
CONCLUSIONS:The results of this study support the use of Danhong injection in the prevention of the Stage 1 of CI-AKI.
