Clinical significance of PD
10.11817/j.issn.1672-7347.2020.190101
- Author:
Junmi LU
1
;
Juan FENG
2
;
Hongmei ZHENG
3
;
Qiuyuan WEN
3
;
Songqing FAN
4
Author Information
1. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011. 1136980635@qq.com.
2. Department of Laboratory, Hunan Prevention and Treatment Institute for Occupational Diseases, Changsha 410007, China.
3. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011.
4. Department of Pathology, Second Xiangya Hospital, Central South University, Changsha 410011. songqingfan@csu.edu.cn.
- Publication Type:Journal Article
- Keywords:
molecular marker;
non-small cell lung cancer;
prognosis;
programmed cell death- ligand 1
- MeSH:
Adenocarcinoma of Lung;
B7-H1 Antigen/genetics*;
Biomarkers, Tumor;
Carcinoma, Non-Small-Cell Lung/surgery*;
Humans;
Lung Neoplasms/surgery*;
Patients;
Prognosis
- From:
Journal of Central South University(Medical Sciences)
2020;45(10):1149-1154
- CountryChina
- Language:English
-
Abstract:
OBJECTIVES:To explore the expression of programmed death ligand-1 (PD-L1) as well as the correlation between the expression and the clinicopathological features or prognosis in non-small cell lung cancer (NSCLC).
METHODS:The expression of PD-L1 protein in 254 cases of surgically resected lung adenocarcinoma (L-ADC), 228 cases of surgically resected lung squamous cell cancer (L-SCC), and 99 cases of non-cancerous control lung tissues was detected with immunohistochemical SP method. The correlation between the PD-L1 expression and clinicopathological features was analyzed. Kaplan-Meier univariate and Cox multivariate regression analyses were performed to assess the prognosis of patients with L-ADC and L-SCC, respectively.
RESULTS:Positive percentage of PD-L1 protein expression was higher in the tissues of L-ADC and L-SCC than that in the non-cancerous control lung tissues respectively (both
CONCLUSIONS:The positive percentage of PD-L1 protein expression is higher in the L-SCC patients than that in the L-ADC patients. Positive expression of PD-L1 protein can be served as an independent prognostic factor of poor prognosis in the patients with L-ADC.
