Effects of Liuwei Dihuang Decoction (Yukmijihwang-tang) on Physical Fatigue by Regulating Neurotransmitters in Brain.
10.1007/s11655-019-3157-9
- Author:
Ji-Ye KEE
1
;
Seung-Heon HONG
1
;
Jin-Han PARK
2
Author Information
1. Department of Oriental Pharmacy, College of Pharmacy, Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Jeonbuk, 54538, Republic of Korea.
2. Division of Bio-technology and Convergence, Daegu Hanny University, Gyeongbuk, 8578, Republic of Korea. jinhan@dhu.ac.kr.
- Publication Type:Journal Article
- Keywords:
Chinese medicine;
HSP70;
Liuwei Dihuang Decoction;
Yukmijihwang-tang;
fatigue;
forced swimming test;
neurotransmitter
- From:
Chinese journal of integrative medicine
2020;26(11):839-844
- CountryChina
- Language:English
-
Abstract:
OBJECTIVE:To study the effect of Liuwei Dihuang Decoction () or Yukmijihwangtang (YJT) on endurance exercise by in vivo experiment.
METHODS:ICR mice were randomly divided into the control group (distilled water) and the YJT groups (1, 10, 100 mg/kg), 5 animals per group. YJT and distilled water were orally administered. The anti-fatigue effect of YJT was evaluated by open fifiled test (OFT), forced swimming test (FST), and tail suspension test (TST).
RESULTS:In the OFT, YJT signifificantly increased the total movement distance in a dose-dependent manner. Additionally, treatment with YJT signifificantly decreased immobility time in the FST and the TST. Various neurotransmitters such as norepinephrine (NE), serotonin (5-HT), dopamine (DA) levels were increased by FST. Administration of YJT down-regulated the expression levels of NE, 5-HT, 5-hydroxyindole-acetic acid (5-HIAA), and DA in the brain stem and hypothalamus of mice. Moreover, protein expression of HSP70 in mice liver and heart muscles was signifificantly increased in the YJT groups.
CONCLUSIONS:YJT could ameliorate fatigue and enhance exercise tolerance through suppressing of brain monoamines including NE, 5-HT, 5-HIAA, and DA in FST mice model.
