CONFOCAL LASER SCANNING MICROSCOPY STUDY ON INTERFACE BONE AND TITANIUM IMPLANT COATED BY CHITOSAN.
- Author:
Yeun Chun PARK
1
;
Byoung Gun AN
;
Young Joo PARK
;
Yong Chan LEE
;
Byoung Wouck CHO
Author Information
1. Department OMFS, College of Medicine, Hallym University.
- Publication Type:Original Article
- Keywords:
confocal laser scanning microscopy;
chitosan;
initial stability
- MeSH:
Artifacts;
Biopsy;
Bone Density;
Chitosan*;
Comprehension;
Microscopy, Confocal*;
Osseointegration;
Tibia;
Titanium*
- From:Journal of the Korean Association of Oral and Maxillofacial Surgeons
1998;24(4):440-447
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The purpose of present study was to observe the radiographic finding and histologic response by Confocal Laser Scanning Microscopy(CLSM) on interface of the bone and titanium implant coated by chitosan. The tissue of rabbit tibiae to the surgical placement titanium implant coated by chitosan was examined at 3, 9 and 24 days postoperatively. The radiographic finding showed that surrounding bone density of implants was not significantly different compare with the bone on 3 and 9 days group. A large amount new bone was formed on 24 days group, the reason was osteconduction activity by chitosan. The CLSM analysis show that the surface coating by chitosan filled the gap between bone and implant on 3 days group and filled by mew born on 9 days group. On 24 days group, the bone and titanium surface was filled by lamella bone. This results indicated that this enhanced the initial stability of implant significantly and chitosan induced osseointegration around implant. CLSM allows the non-destrutive histo-tomography of bone biopsy as well as clinical practice. We conclude that CLSM allowed a good comprehension of the nature of bone-implant contact, avoiding artifacts due to the thickness of the specimen.
