Urinary N-terminal pro-B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study.
10.1186/s12199-021-00970-0
- Author:
Keisuke YAMASAKI
1
;
Jun HATA
2
;
Tomomi IDE
3
;
Takuya NAGATA
1
;
Satoko SAKATA
1
;
Daigo YOSHIDA
1
;
Takanori HONDA
1
;
Yoichiro HIRAKAWA
1
;
Toshiaki NAKANO
4
;
Takanari KITAZONO
4
;
Hiroyuki TSUTSUI
3
;
Toshiharu NINOMIYA
1
Author Information
1. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
2. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hata.jun.759@m.kyushu-u.ac.jp.
3. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
4. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
- Publication Type:Journal Article
- Keywords:
Biomarker;
Cardiovascular disease;
General populations;
Prospective study;
Urinary NT-proBNP
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Biomarkers/urine*;
Cardiovascular Diseases/urine*;
Female;
Heart Failure/diagnosis*;
Humans;
Incidence;
Japan/epidemiology*;
Male;
Middle Aged;
Natriuretic Peptide, Brain/urine*;
Peptide Fragments/urine*;
Prospective Studies;
Risk Assessment
- From:Environmental Health and Preventive Medicine
2021;26(1):47-47
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Epidemiological evidence has shown that serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations, a diagnostic biomarker for heart failure, are positively associated with cardiovascular risk. Since NT-proBNP in serum is excreted in urine, it is hypothesized that urinary NT-proBNP concentrations are correlated with serum concentrations and linked with cardiovascular risk in the general population.
METHODS:A total of 3060 community-dwelling residents aged ≥ 40 years without history of cardiovascular disease (CVD) were followed up for a median of 8.3 years (2007-2015). Serum and urinary concentrations of NT-proBNP at baseline were compared. The hazard ratios (HRs) and their 95% confidence intervals (CIs) for the association between NT-proBNP concentrations and the risk of developing CVD were computed using the Cox proportional hazards model.
RESULTS:The median values (interquartile ranges) of serum and urinary NT-proBNP concentrations at baseline were 56 (32-104) pg/mL and 20 (18-25) pg/mL, respectively. There was a strong quadratic correlation between the serum and urinary concentrations of NT-proBNP (coefficient of determination [R
CONCLUSIONS:The present study demonstrated that urinary NT-proBNP concentrations were well-correlated with serum concentrations and were positively associated with cardiovascular risk. Given that urine sampling is noninvasive and does not require specially trained personnel, urinary NT-proBNP concentrations have the potential to be an easy and useful biomarker for detecting people at higher cardiovascular risk.
