Sex differences in the link between blood cobalt concentrations and insulin resistance in adults without diabetes.
10.1186/s12199-021-00966-w
- Author:
Yong CHEN
1
;
Haobin HUANG
2
;
Xiaowei HE
3
;
Weiwei DUAN
4
;
Xuming MO
5
Author Information
1. Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China.
2. Department of Cardiovascular Surgery, the First Affiliated Hospital, Nanjing Medical University, Nanjing, 210029, Jiangsu Province, China.
3. Department of Endocrinology and Metabolism/Diabetes Care and Research Center, Nanjing Medical University Affiliated Geriatric Hospital/Jiangsu Province Geriatric Hospital, Jiangsu Province Official Hospital/Jiangsu Province Institute of Geriatrics, Nanjing, China.
4. Department of Bioinformatics, School of Biomedical Engineering and Informatics, Nanjing Medical University, 101 Longmian Avenue, Nanjing, 211166, China. passion@njmu.edu.cn.
5. Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, 72 Guangzhou Road, Nanjing, 210008, China. mohsuming15@njmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Cobalt;
HOMA-IR;
Insulin resistance;
NHANES
- MeSH:
Adult;
Aged;
Aged, 80 and over;
Cobalt/blood*;
Cross-Sectional Studies;
Environmental Pollutants/blood*;
Female;
Homeostasis;
Humans;
Insulin/blood*;
Insulin Resistance;
Male;
Middle Aged;
Nutrition Surveys;
Sex Factors;
United States;
Young Adult
- From:Environmental Health and Preventive Medicine
2021;26(1):42-42
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Little is known about the effects of environmental cobalt exposure on insulin resistance (IR) in the general adult population. We investigated the association between cobalt concentration and IR.
METHODS:A total of 1281 subjects aged more than 20 years with complete blood cobalt data were identified from the National Health and Nutrition Examination Survey (NHANES) 2015-2016 cycle. Blood cobalt levels were analyzed for their association with IR among all populations and subgroups by sex. Regression coefficients and 95% confidence intervals (CIs) of blood cobalt concentrations in association with fasting glucose, insulin and homeostatic model assessment of insulin resistance (HOMA-IR) were estimated using multivariate linear regression after adjusting for age, sex, ethnicity, alcohol consumption, body mass index, education level, and household income. A multivariate generalized linear regression analysis was further carried out to explore the association between cobalt exposure and IR.
RESULTS:A negative association between blood cobalt concentration (coefficient = - 0.125, 95% CI - 0.234, - 0.015; P = 0.026) and HOMA-IR in female adults in the age- and sex-adjusted model was observed. However, no associations with HOMA-IR, fasting glucose, or insulin were found in the overall population. In the generalized linear models, participants with the lowest cobalt levels had a 2.74% (95% CI 0.04%, 5.50%) increase in HOMA-IR (P for trend = 0.031) compared with subjects with the highest cobalt levels. Restricted cubic spline regression suggested that a non-linear relationship may exist between blood cobalt and HOMA-IR.
CONCLUSIONS:These results provide epidemiological evidence that low levels of blood cobalt are negatively associated with HOMA-IR in female adults.
