Possible mechanisms underlying the association between human T-cell leukemia virus type 1 (HTLV-1) and hypertension in elderly Japanese population.
10.1186/s12199-021-00938-0
- Author:
Yuji SHIMIZU
1
;
Kazuhiko ARIMA
2
;
Yuko NOGUCHI
3
;
Shin-Ya KAWASHIRI
3
;
Hirotomo YAMANASHI
4
;
Mami TAMAI
5
;
Yasuhiro NAGATA
6
;
Takahiro MAEDA
3
Author Information
1. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan. shimizu@osaka-ganjun.jp.
2. Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
3. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki-shi, Sakamoto 1-12-4, Nagasaki, 852-8523, Japan.
4. Department of General Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
5. Department of Island and Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
6. Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
- Publication Type:Journal Article
- Keywords:
Aging;
Atherosclerosis;
HTLV-1;
Hypertension;
Platelet
- MeSH:
Aged;
Aged, 80 and over;
Carotid Artery Diseases/virology*;
Cross-Sectional Studies;
Female;
HTLV-I Infections/complications*;
Human T-lymphotropic virus 1/physiology*;
Humans;
Hypertension/virology*;
Japan/epidemiology*;
Male;
Middle Aged
- From:Environmental Health and Preventive Medicine
2021;26(1):17-17
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:Human T-cell leukemia virus type 1 (HTLV-1) activates inflammatory cascades by activating the NF-κB pathway. The minor allele of single nucleotide polymorphism (SNP) in breast cancer suppressor BRCA1-associated protein (BRAP), which has a common etiology with HTLV-1 infection, has been reported to be positively associated with carotid atherosclerosis, but inversely associated with hypertension. Therefore, HTLV-1 infection may be inversely associated with hypertension by activating endothelial maintenance, including atherosclerosis. To clarify these associations, a cross-sectional study was conducted using 2989 Japanese individuals aged 60-99 years participating in a general health check-up.
METHODS:Logistic regression models were used to clarify the association between HTLV-1 and hypertension. Platelet levels stratified analyses were also performed since platelet production, which plays a crucial role in endothelium maintenance, can be stimulated by activating the NF-κB pathway.
RESULTS:HTLV-1 infection was found to be significantly inversely associated with hypertension, particularly in subjects with high platelet levels (≥ second tertiles of platelet levels); the fully adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were 0.75 (0.62, 0.92) for total and 0.64 (0.50, 0.82) for high platelet levels, respectively. Further analysis of the non-hypertensive subjects demonstrated that HTLV-1 infection was significantly positively associated with atherosclerosis in subjects with the highest tertile of platelet levels (2.11 [1.15, 3.86]) but not in subjects with low platelet levels (first and second tertiles of platelet level) (0.89 [0.57, 1.39]).
CONCLUSION:Asymptomatic HTLV-1 infection is inversely associated with hypertension, possibly by activating endothelial maintenance, including atherosclerosis progression.
