Lack of association between multiple polymorphisms in aryl hydrocarbon receptor (AhR) gene and cancer susceptibility.
10.1186/s12199-020-00907-z
- Author:
He LI
1
;
Li LUO
2
;
Dan WANG
3
;
Jun DUAN
3
;
Rui ZHANG
4
Author Information
1. Department of Respiratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, No. 76, Linjiang Road, Chongqing, 400010, Yuzhong District, China.
2. State Key Laboratory of Trauma, Burns and Combined Injury, Department of Wound Infection and Drug, Army Medical Center (Daping Hospital), Army Medical University, No. 10 Changjiang Branch Road, Chongqing, 400042, Yuzhong District, China.
3. Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, Yuzhong District, China.
4. Department of Respiratory Medicine, The First Affiliated Hospital of Chongqing Medical University, No. 1, Youyi Road, Chongqing, 400016, Yuzhong District, China. zhrui21193@163.com.
- Publication Type:Meta-Analysis
- Keywords:
Aryl hydrocarbon receptor;
Cancer risk;
Meta-analysis;
Polymorphism;
Susceptibility
- MeSH:
Basic Helix-Loop-Helix Transcription Factors/genetics*;
Confidence Intervals;
Genetic Predisposition to Disease/epidemiology*;
Humans;
Neoplasms/genetics*;
Odds Ratio;
Polymorphism, Genetic;
Receptors, Aryl Hydrocarbon/genetics*
- From:Environmental Health and Preventive Medicine
2020;25(1):79-79
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:The aryl hydrocarbon receptor (AhR) is commonly known as an environmental sensor. Polymorphisms in AhR gene have been implicated in susceptibility to cancer. However, the results were controversial. This study was conducted to quantitatively summarize the association between AhR polymorphisms and cancer risk by meta-analysis.
METHODS:Relevant reports were searched in four databases (Embase, PubMed, Wanfang, and China National Knowledge Infrastructure). We used pooled odds ratio (OR) and 95% confidence interval (95% CI) to evaluate the strength of the association in both standard and cumulative meta-analysis. Subgroup and sensitivity analysis was also performed, and between-study heterogeneity and publication bias were checked.
RESULTS:A total of seventeen studies referring to three AhR polymorphisms (rs2066853, rs7796976, and rs2074113) were identified, and 9557 cases and 10038 controls were included. There was no statistically significant association of AhR rs2066853 polymorphism with cancer risk in the overall population, and the negative results were repeated in subgroup analysis by the ethnicity and cancer type. Concerning AhR rs7796976 or rs2074113 polymorphism, no significant correlation was detected. Moreover, these non-significant findings were stable in sensitivity analysis, and the cumulative meta-analysis indicated a trend of no significant link between this three AhR polymorphisms and cancer risk as more data accumulated over time.
CONCLUSION:This meta-analysis provides evidence that the rs2066853, rs7796976, or rs2074113 polymorphism in AhR gene is not a susceptible predictor of cancer. Further clinical and functional investigation between AhR polymorphisms and cancer susceptibility are needed.
