Associations between thyroid-stimulating hormone and hypertension according to thyroid cyst status in the general population: a cross-sectional study.
10.1186/s12199-020-00910-4
- Author:
Yuji SHIMIZU
1
;
Yuko NABESHIMA-KIMURA
2
;
Shin-Ya KAWASHIRI
3
;
Yuko NOGUCHI
3
;
Yasuhiro NAGATA
4
;
Takahiro MAEDA
3
;
Naomi HAYASHIDA
5
Author Information
1. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan. shimizu@osaka-ganjun.jp.
2. Department of Radiation Health Management, Fukushima Medical University, Fukushima, Japan.
3. Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
4. Center for Comprehensive Community Care Education, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
5. Division of Promotion of Collaborative Research on Radiation and Environment Health Effects, Atomic Bomb Disease Institute, Nagasaki University, Nagasaki, Japan.
- Publication Type:Journal Article
- Keywords:
Cross-sectional study;
Hypertension;
Normal thyroid function;
Thyroid cysts;
Thyroid-stimulating hormone
- MeSH:
Aged;
Cross-Sectional Studies;
Cysts/etiology*;
Female;
Humans;
Hypertension/metabolism*;
Japan;
Male;
Middle Aged;
Thyroid Diseases/etiology*;
Thyroid Gland/pathology*;
Thyrotropin/metabolism*
- From:Environmental Health and Preventive Medicine
2020;25(1):69-69
- CountryJapan
- Language:English
-
Abstract:
BACKGROUND:The absence of thyroid cysts may indicate latent thyroid damage, as demonstrated in our previous study. However, the association between the absence of thyroid cysts and latent functional damage of the thyroid is unknown. At low thyroid hormone productivity, which may be associated with latent functional damage of the thyroid, the association between thyroid-stimulating hormone (TSH) and hypertension might be enhanced. Therefore, we evaluated the association between TSH level and hypertension stratified by thyroid cyst status.
METHODS:We conducted a cross-sectional study of 1724 euthyroid Japanese individuals aged 40-74 years who participated in an annual health checkup in 2014.
RESULTS:In the study population, 564 and 686 participants had thyroid cysts and hypertension, respectively. A significant positive association was observed between TSH and hypertension in subjects without a thyroid cyst but not in subjects with thyroid cysts. There was a significant positive association between hypertension and TSH in subjects without a thyroid cyst (odds ratio [OR] 1.27; 95% confidence intervals [CI] 1.01, 1.61) but not in subjects with thyroid cysts (OR 0.79; CI 0.57, 1.09) in the model fully adjusted for known confounding factors. The correlation between the TSH and free triiodothyronine (fee T3) levels (simple correlation coefficient [r] = - 0.13, p < 0.01) was stronger in the subjects without thyroid cysts than in those with thyroid cysts (r = - 0.03, p = 0.525).
CONCLUSIONS:TSH is positively associated with hypertension only in individuals without thyroid cysts. The correlation between the TSH and free T3 levels was stronger in the subjects without thyroid cysts than in those with thyroid cysts. Therefore, the absence of thyroid cysts could be related to the association between TSH level and hypertension, possibly by indicating that the subjects without thyroid cysts had limited thyroid hormone reserves. Therefore, the absence of thyroid cysts could indicate the latent functional damage of the thyroid.
