Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).

Toshiharu Ninomiya; Shigeyuki Nakaji; Tetsuya Maeda; Masahito Yamada; Masaru Mimura; Kenji Nakashima; Takaaki Mori; Minoru Takebayashi; Tomoyuki Ohara; Jun Hata; Yoshihiro Kokubo; Kazuhiro Uchida; Yasuyuki Taki; Shuzo Kumagai; Koji Yonemoto; Hisako Yoshida; Kaori Muto; Yukihide Momozawa; Masato Akiyama; Michiaki Kubo; Manabu Ikeda; Shigenobu Kanba; Yutaka Kiyohara

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Study design and baseline characteristics of a population-based prospective cohort study of dementia in Japan: the Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD).

Author: Toshiharu NINOMIYA ¹ ; Shigeyuki NAKAJI ² ; Tetsuya MAEDA ³ ; Masahito YAMADA ⁴ ; Masaru MIMURA ⁵ ; Kenji NAKASHIMA ⁶ ; Takaaki MORI ⁷ ; Minoru TAKEBAYASHI ⁸ ; Tomoyuki OHARA ⁹ ; Jun HATA ¹⁰ ; Yoshihiro KOKUBO ¹¹ ; Kazuhiro UCHIDA ¹² ; Yasuyuki TAKI ¹³ ; Shuzo KUMAGAI ¹⁴ ; Koji YONEMOTO ¹⁵ ; Hisako YOSHIDA ¹⁶ ; Kaori MUTO ¹⁷ ; Yukihide MOMOZAWA ¹⁸ ; Masato AKIYAMA ¹⁹ ; Michiaki KUBO ²⁰ ; Manabu IKEDA ²¹ ; Shigenobu KANBA ⁹ ; Yutaka KIYOHARA ²⁰
Author Information

1. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. nino@eph.med.kyushu-u.ac.jp.
2. Department of Social Medicine, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
3. Division of Neurology and Gerontology, Department of Internal Medicine, School of Medicine, Iwate Medical University, Morioka, Japan.
4. Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan.
5. Department of Neuropsychiatry, Keio University School of Medicine, Tokyo, Japan.
6. National Hospital Organization, Matsue Medical Center, Matsue, Japan.
7. Department of Neuropsychiatry, Neuroscience Ehime University Graduate School of Medicine, Ehime, Japan.
8. Department of Neuropsychiatry, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
9. Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan.
10. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
11. Department of Preventive Cardiology, National Cerebral and Cardiovascular Center, Suita, Japan.
12. Department of Health Promotion, School of Health and Nutrition Sciences, Nakamura-Gakuen University, Fukuoka, Japan.
13. Department of Nuclear Medicine and Radiology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
14. Kumagai Institute of Health Policy, Fukuoka, Japan.
15. Division of Biostatistics, School of Health Sciences, Faculty of Medicine, University of the Ryukyus, Nishihara, Japan.
16. Department of Medical Statistics, Osaka City University Graduate School of Medicine, Osaka, Japan.
17. Department of Public Policy, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan.
18. Laboratory for Genotyping Development, RIKEN Center for Integrative Medical Sciences, Saitama, Japan.
19. Department of Ocular Pathology and Imaging Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
20. Hisayama Research Institute for Lifestyle Diseases, Fukuoka, Japan.
21. Department of Psychiatry, Osaka University Medical School, Suita, Japan.
Collective Name:JPSFC-AD Study Group
Publication Type:Journal Article
Keywords: Alzheimer’s disease; Dementia; Prospective cohort study
MeSH: Aged; Alzheimer Disease/genetics*; Dementia/genetics*; Environment; Female; Humans; Incidence; Japan/epidemiology*; Male; Middle Aged; Prevalence; Prospective Studies; Risk Factors
From:Environmental Health and Preventive Medicine 2020;25(1):64-64
CountryJapan
Language:English
Abstract: BACKGROUND:The burden of dementia is growing rapidly and has become a medical and social problem in Japan. Prospective cohort studies have been considered an effective methodology to clarify the risk factors and the etiology of dementia. We aimed to perform a large-scale dementia cohort study to elucidate environmental and genetic risk factors for dementia, as well as their interaction.
METHODS:The Japan Prospective Studies Collaboration for Aging and Dementia (JPSC-AD) is a multisite, population-based prospective cohort study of dementia, which was designed to enroll approximately 10,000 community-dwelling residents aged 65 years or older from 8 sites in Japan and to follow them up prospectively for at least 5 years. Baseline exposure data, including lifestyles, medical information, diets, physical activities, blood pressure, cognitive function, blood test, brain magnetic resonance imaging (MRI), and DNA samples, were collected with a pre-specified protocol and standardized measurement methods. The primary outcome was the development of dementia and its subtypes. The diagnosis of dementia was adjudicated by an endpoint adjudication committee using standard criteria and clinical information according to the Diagnostic and Statistical Manual of Mental Disorders, 3rd Revised Edition. For brain MRI, three-dimensional acquisition of T1-weighted images was performed. Individual participant data were pooled for data analyses.
RESULTS:The baseline survey was conducted from 2016 to 2018. The follow-up surveys are ongoing. A total of 11,410 individuals aged 65 years or older participated in the study. The mean age was 74.4 years, and 41.9% were male. The prevalence of dementia at baseline was 8.5% in overall participants. However, it was 16.4% among three sites where additional home visit and/or nursing home visit surveys were performed. Approximately two-thirds of dementia cases at baseline were Alzheimer's disease.
CONCLUSIONS:The prospective cohort data from the JPSC-AD will provide valuable insights regarding the risk factors and etiology of dementia as well as for the development of predictive models and diagnostic markers for the future onset of dementia. The findings of this study will improve our understanding of dementia and provide helpful information to establish effective preventive strategies for dementia in Japan.