Human papillomavirus infection in men with condyloma acuminatum: Genotype analysis of 70 cases.
- Author:
Qiang LI
1
;
Yao-Wu GAO
1
;
Hong-Qiang WANG
1
;
Lei YU
1
;
Tao JING
1
;
Shen-Qian LI
1
;
Pei-Tao WANG
1
Author Information
1. Department of Andrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266001, China.
- Publication Type:Journal Article
- Keywords:
condyloma acuminatum;
gene subtype;
male;
human papilloma virus
- MeSH:
Adult;
Condylomata Acuminata/virology*;
DNA, Viral/genetics*;
Genotype;
Humans;
Male;
Papillomaviridae/genetics*;
Papillomavirus Infections/virology*;
Young Adult
- From:
National Journal of Andrology
2020;26(10):906-910
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the distribution of the gene subtypes of human papillomavirus (HPV) in male patients with condyloma acuminatum (CA) and analyze the characteristics of the gene subtypes.
METHODS:We extracted genomic DNA of the HPV virus from the genital tissue of 70 male CA patients, detected the DNA subtypes of HPV using the PCR-reverse dot hybridization technique, and analyzed the rates of different subtypes identified and their characteristics of distribution in different age groups.
RESULTS:The male HPV-positive patients were mainly infected at the age of 20－39 years, primarily with high- and low-risk mixed infection of various subtypes, which accounted for 61.54% in the 20- to 29-year-olds and 42.86% in the 30- to 39-year-olds. Among the 70 CA patients, 22 HPV subtypes were identified, the top five subtypes including HPV 11 (21.08%), HPV 6 (19.46%), HPV 42 (6.49%), HPV 59 (6.49%) and HPV 53 (5.95%); 20 infected with a single subtype (28.57%), 19 with two subtypes (27.14%) and 31 with three or more (44.29%); and 30 infected with a low-risk single subtype (42.86%) and 40 with both high- and low-risk multiple subtypes (57.14%).
CONCLUSIONS:Male patients with CA are mainly infected with HPV 11 and HPV 6, with a significantly higher rate of multi-subtype than single-subtype infection, and the multi-subtype patients chiefly with high- and low-risk mixed infection. Men aged 20－39 years old are most commonly affected by CA.
