Advancement of Cancer Associated Fibroblasts-derived Exosomes in Lung Cancer.
10.3779/j.issn.1009-3419.2021.102.07
- Author:
Cheng SHEN
1
;
Jue LI
1
;
Jialong LI
1
;
Guowei CHE
1
Author Information
1. Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.
- Publication Type:Journal Article
- Keywords:
Cancer-associated fibroblasts;
Exosomes;
Lung neoplasms;
Tumor microenvironment
- From:
Chinese Journal of Lung Cancer
2021;24(3):212-216
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment (TME) is a dynamic network distributed around tumor cells. Cancer-associated fibroblasts (CAFs), as an important component of the TME, are not only closely related to normal fibroblasts, but also can secrete a variety of substances to participate in the regulation of the TME. Exosomes, one of the substances from CAFs, can promote the formation and development of lung cancer, including promoting the formation of TME, increasing pulmonary tumor cell invasion and metastasis, mediating pulmonary tumor immunosuppression and participating in radiotherapy and chemotherapy resistance. This article reviews the current research status and progress of cancer associated fibroblasts-derived exosomes in lung cancer.
.
