Clinical Features of EGFR Mutation Negative in Patients
with Non-small Cell Lung Cancer and Brain Metastases.
10.3779/j.issn.1009-3419.2020.102.48
- Author:
Yixiang ZHU
1
;
Ye ZHANG
1
Author Information
1. Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,
Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
- Publication Type:Journal Article
- Keywords:
Brain metastases;
Clinical features;
Lung neoplasms;
Mutation negative
- From:
Chinese Journal of Lung Cancer
2021;24(1):43-48
- CountryChina
- Language:Chinese
-
Abstract:
In addition to rare incidence of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1 receptor kinase (ROS1) positive patients, patients with brain metastases of non-small cell lung cancer (NSCLC) without epidermal growth factor receptor (EGFR) sensitive mutation have no effective systemic therapy at present, and the overall prognosis is poor. Since the low blood-brain barrier permeability of chemotherapy drugs, the local treatment plays an important role in brain metastases. To understand the clinical characteristics and treatment of brain parenchymal metastases in patients with NSCLC and EGFR mutation negative, we reviewed the incidence, onset time, site, numbers, size, symptom, therapeutic effect and disease evolution in them, which can provide reference for interventional timing and local treatment technology selection of local treatment for brain parenchymal metastases.
.
