Amplification of Extrachromosomal Oncogene and Tumorigenesis and Development.
10.3779/j.issn.1009-3419.2020.101.48
- Author:
Yutong WANG
1
;
Fan YE
1
;
Xiao ZHANG
1
;
Ruihan ZOU
1
;
Mingyuan WANG
1
;
Kai YU
1
;
Shiyun CUI
2
Author Information
1. Nanjing Medical University, Nanjing 211166, China.
2. Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
- Publication Type:Journal Article
- Keywords:
Double minutes;
Extrachromosomal DNA;
Extrachromosomal circular DNA;
Tumor
- From:
Chinese Journal of Lung Cancer
2020;23(12):1101-1107
- CountryChina
- Language:Chinese
-
Abstract:
Extrachromosomal DNA (ecDNA) is a small segment of circular DNA located outside the chromosome, which has the function of self-replication. Recently, amplification of oncogenes on ecDNA has been proved to be a common phenomenon in tumor cells, and has some characteristics worth studying, such as correlation with patients' poor prognosis. Multiple chromosomal events are involved in the formation of ecDNA, and its amplification can directly increase the number of DNA copies of extra-chromosomal oncogenes and accelerate the generation and development of tumors. Moreover, the segregation pattern of unequal transmission of parental ecDNA cells to offspring not only increases tumor heterogeneity, but also enhances tumor adaptation to environment and response to therapy. This article reviews the current status and potential significance of ecDNA in tumor cells.
.
