Research Advances on the Senescence Mechanism of Bone Marrow Mesenchymal Stem Cells Derived from Patients with Myelodysplastic Syndrome--Review.
10.19746/j.cnki.issn.1009-2137.2021.03.056
- Author:
Ming-Jie TIAN
1
;
Yan-Bin PANG
1
;
Li-Xia FAN
2
Author Information
1. Department of Hematology, Afilliatied Hospital of Hebei Universtity, Baoding 071000, Hebei Province, China.
2. Department of Hematology, Afilliatied Hospital of Hebei Universtity, Baoding 071000, Hebei Province, China,E-mail: 2530135881@qq.com.
- Publication Type:Review
- MeSH:
Bone Marrow;
Bone Marrow Cells;
Cellular Senescence;
Humans;
Mesenchymal Stem Cells;
Myelodysplastic Syndromes
- From:
Journal of Experimental Hematology
2021;29(3):1002-1006
- CountryChina
- Language:Chinese
-
Abstract:
Emerging data have demonstrated that bone marrow mesenchymal stem cells (MSCs) play important roles in the progression of myelodysplastic syndrome (MDS). Experiments in vitro have showed that MSCs derived from MDS patients (MDS-MSC) exhibit the biological characteristics of cell senescence. Although the underlying mechanisms that regulate cell senescence need to be further elucidated, existing researches indicate that the mechanisms of MDS-MSC senescence have significant heterogeneity. Depth understanding of the underlying mechanisms involved in cell senescence of MDS-MSC are crucial to explore the potential therapeutic target of MDS. Therefore, this review summarizes research advances related with MSC senescence, such as MDS-MSC intrinsic changes in telomere shortening, DNA methylation status, oxidative stress and signal pathways regulating cell senescence in recent years.
