The Role of Zyxin in Regulating Platelet Cytoskeleton Distribution.
10.19746/j.cnki.issn.1009-2137.2021.03.035
- Author:
Bin CHENG
1
;
Rong YAN
1
;
Su-Qin ZHANG
1
;
Meng-Nan YANG
1
;
Ke-Sheng DAI
2
Author Information
1. Medical College of Soochow University, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University and Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu Province, China.
2. Medical College of Soochow University, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University and Collaborative Innovation Center of Hematology, State Key Laboratory of Radiation Medicine and Protection, Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou 215006, Jiangsu Province, China,E-mail: kdai@suda.edu.cn.
- Publication Type:Journal Article
- MeSH:
Actinin;
Actins;
Animals;
Blood Platelets;
Cytoskeleton;
Mice;
Zyxin
- From:
Journal of Experimental Hematology
2021;29(3):876-880
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the regulatory effect of zyxin on the distribution of platelet cytoskeleton.
METHODS:Platelets were isolated from zyxin-knockout (Zyx
RESULTS:After zyxin gene was knockout, the expressions of cytoskeleton proteins β-actin, α-actinin, filamin A, and myosin Ⅱ A in resting and Jas-induced platelets were significantly increased. In the platelet spreading on fibrinogen surface, F-actin was increased in Zyx
CONCLUSION:Zyxin significantly regulates the distribution of platelet cytoskeleton, which plays an important role in maintaining platelet cytoskeleton homeostasis.
