Clinical Significance of Pretransplant Serum Ferritin Level in Patients with Prolonged Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation.
10.19746/j.cnki.issn.1009-2137.2021.03.034
- Author:
Wen-Jing MIAO
1
,
2
,
3
;
Jia-Qian QI
1
,
4
;
Bao-Quan SONG
1
,
2
,
3
;
Rui ZHANG
1
,
2
,
3
;
Chang-Geng RUAN
1
,
4
;
De-Pei WU
1
,
2
,
3
;
Yue HAN
1
,
2
,
5
Author Information
1. Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University
2. Suzhou 215000, Jiangsu Province, China,Institute of Blood and Marrow Transplantation
3. Soochow University, Suzhou 215000, Jiangsu Province, China,Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Soochow University, Suzhou 215000, Jiangsu Province, China.
4. Suzhou 215000, Jiangsu Province, China,Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Soochow University, Suzhou 215000, Jiangsu Province, China.
5. Soochow University, Suzhou 215000, Jiangsu Province, China,Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Soochow University, Suzhou 215000, Jiangsu Province, China,E-mail: hanyue@suda.edu.cn.
- Publication Type:Journal Article
- MeSH:
Ferritins;
Hematopoietic Stem Cell Transplantation;
Humans;
Retrospective Studies;
Thrombocytopenia;
Transplantation, Homologous
- From:
Journal of Experimental Hematology
2021;29(3):869-875
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the correlation between pretransplant serum ferritin (SF) level and prolonged or prolonged isolated thrombocytopenia (PT) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
METHODS:The clinical data of 35 patients with PT after allo-HSCT were retrospectively analyzed, and 35 patients were matched according to age and sex as a controls from 424 allo-HSCT patients with normal platelet count. The serum ferritin level before the transplantation was analyzed. The potential risk factors were analyzed by chi-square test and Fisher's exact test as well as univariate and multivariate logistic regression. The survival curve was estimated by the Kaplan-Meier model to explore its clinical significance. In addition, ROC curve was used to verify the predictive power of SF.
RESULTS:Compared with control group, the SF level in the PT group before transplantation significantly increased (P=0.001). Multivariate analysis results showed that SF level before transplantation was a risk factor for prolonged thrombocytopenia after HSCT, and patients with SF≥1000 ng / ml showed a higher risk of death (P=0.014). ROC curve showed that SF level could be used as a predictor of prolonged thrombocytopenia after allo-HSCT.
CONCLUSION:The SF level before allo-HSCT relates with occurrence and prognosis of PT in patients after allo-HSCT. Detection of SF level can provide guidance for the intervention of prolonged thrombocytopenia after HSCT.
