Diagnostic Cut-Off Value of RDW for Screening Thalassemia and the Combined Determination of MCV, MCH, HBA
10.19746/j.cnki.issn.1009-2137.2021.03.030
- Author:
Qi-Ling SONG
1
;
Yang-Liu GUO
2
;
Yong-Jun HE
3
;
Cheng HE
3
;
Ting ZHANG
3
;
Yan CAI
1
;
Wen LIU
2
;
Xing-Chun ZHU
4
;
Qing-Song LIU
5
Author Information
1. Department of Prenatal Diagnosis of Affiliated Hospital of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Laboratory of Medical Examination of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Translational Medicine Research Center of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China.
2. Laboratory of Medical Examination of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Translational Medicine Research Center of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Department of Laboratory Medicine of Affiliated Hospital, North Sichuan Medical College, Nanchong 637000, Sichuan Province, China.
3. Department of Prenatal Diagnosis of Affiliated Hospital of North Sichuan Medical College,,Nanchong 637000, Sichuan Province, China.
4. Department of Laboratory Medicine, The People's Hospital of Kaizhou District, Chongqing 405400, China,E-mail: zhuxingch@aliyun.com.
5. Department of Prenatal Diagnosis of Affiliated Hospital of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Laboratory of Medical Examination of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,Translational Medicine Research Center of North Sichuan Medical College,Nanchong 637000, Sichuan Province, China,E-mail: 35590551@qq.com.
- Publication Type:Journal Article
- MeSH:
Erythrocyte Indices;
Hemoglobin A2/analysis*;
Humans;
Mass Screening;
Research;
Thalassemia/diagnosis*
- From:
Journal of Experimental Hematology
2021;29(3):847-852
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the value of red cell distribution width (RDW), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and hemoglobin (Hb) A2 combined determination scheme for screening thalassemia.
METHODS:The RDW levels of thalassemia group and healthy control group were detected and compared. The efficiency of RDW for screening thalassemia was evaluated by receiver operating characteristic (ROC) curve. The diagnostic cut-off value of RDW was also acquired by Youden index. Then, 3 groups for thalassemia screening scheme were set, including MCV+MCH+HBA
RESULTS:The RDW level in thalassemia group was significantly higher than that in healthy control group (P<0.05). The diagnostic cut-off value for screening thalassemia was RDW>15.15, when the Youden index was the biggest among all data. The sensitivity, specificity, positive predictive value, negative predictive value, false negative rate and consistency rate of MCV+MCH+RDW(>15.15)+HBA
CONCLUSION:The diagnostic cut-off value of RDW for thalassemia screening has been established. The group of MCV(<82.0 fl)+MCH(<27.0 pg)+HBA
