Clinical Features and Prognostic Factors of Patients with Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2021.03.019
- Author:
Ying-Ying GONG
1
;
Xiao-Shuang YAN
1
;
Ye-Min WANG
1
;
Jin-Lan PAN
1
;
Ying-Ying ZHAI
1
;
Su-Ning CHEN
1
;
Dan-Dan LIU
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, Jiangsu Province, China.
2. Department of Hematology, The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, Suzhou 215006, Jiangsu Province, China,E-mail: liudd_2006@126.com.
- Publication Type:Journal Article
- MeSH:
Disease-Free Survival;
Hematopoietic Stem Cell Transplantation;
Humans;
Middle Aged;
Multiple Myeloma/therapy*;
Prognosis;
Retrospective Studies;
Transplantation, Autologous;
Treatment Outcome
- From:
Journal of Experimental Hematology
2021;29(3):772-780
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To summarize the clinical and Laboratory characteristics of patients with multiple myeloma (MM) and analyze the prognostic factors.
METHODS:Two hundred MM patients were retrospectively analyzed for the following parameters, including peripheral blood, bone marrow morphology, cytogenetics, clinical staging, and response to the chemotherapy in order to summarize related factors affecting overall survival (OS). The prognostic factors were also analyzed.
RESULTS:200 patients with MM were divided into 3 groups according to bone marrow plasma cell percentage (BMPC%) in bone marrow smears: ＜10% group (74 cases, 37.0%), 10%-50% group (75 cases, 37.5%), ＞50% group (51 cases, 25.5%). Compared with the other two groups, patients in BMPC%<10% group were characterized by lower clinical staging levels, lower rates of 13q14 deletion and t(11;14) positive, better response to chemotherapy and favorable three-year OS rate. The univariate analysis showed that prognostic factors indicating favorable outcome as evaluated by OS included age≤55 years old, BMPC%＜10%, WBC＜7.5×10
CONCLUSION:The clinical characteristics are different among MM patients with different BMPC% in bone marrow smears at initial diagnosis, and prognostic analysis shows that the BMPC% in bone marrow smears has an effect on OS rate. BMPC% in bone marrow smears at initial diagnosis, age, WBC, Hb, response to the fourth chemotherapy are also the main factors impacting the prognosis of patients.
