Relationship between IKZF3 Gene Single Nucleotide Polymorphisms and Childhood Acute Lymphoblastic Leukemia.
10.19746/j.cnki.issn.1009-2137.2021.03.006
- Author:
Yan HONG
1
;
Qiang WANG
1
;
Yong-Ling SONG
1
;
Guang-Ming LIU
1
;
Xu YANG
2
;
Mu-Xia YAN
3
Author Information
1. Department of Emergency,Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong Province, China.
2. Department of Hematology,Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong Province, China.
3. Department of Hematology,Guangzhou Women and Children's Medical Center, Guangzhou 510623, Guangdong Province, China,E-mail: zichemama@126.com.
- Publication Type:Journal Article
- MeSH:
Alleles;
Case-Control Studies;
Child;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Ikaros Transcription Factor/genetics*;
Polymorphism, Single Nucleotide;
Precursor Cell Lymphoblastic Leukemia-Lymphoma/genetics*
- From:
Journal of Experimental Hematology
2021;29(3):690-695
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the relationship between single nucleotide polymorphisms (SNPs) of IKAROS family Zinc finger 3 (IKZF3) gene and the risk of acute lymphoblastic leukemia (ALL) in children.
METHODS:The peripheral blood samples from 286 children with ALL and 382 healthy children were collected and divided into ALL group and control group, respectively. The genotypes of IKZF3 gene at rs62066988 C > T and rs12946510 C > T were detected by quantitative PCR with TaqMan detection system, and their correlation with ALL was analyzed.
RESULTS:The distribution frequencies of CC, CT and TT genotypes at rs62066988 in ALL group were 58.39%, 37.06% and 4.55%, respectively, while those in control group were 69.19%, 27.68% and 3.13%, respectively. The distribution frequencies of CC, CT and TT genotypes at rs12946510 in ALL group were 58.16%, 34.75% and 7.09%, respectively, while those in control group were 55.76%, 37.43% and 6.81%, respectively. Compared with the control group, the distribution frequency of CT/TT genotype at rs62066988 was significantly increased in the ALL group (OR=1.59, 95%CI: 1.16-2.19, P=0.004). However, there was no significant difference in the distribution of rs12946510 C > T polymorphism between ALL group and control group.
CONCLUSION:The CT/TT genotype of IKZF3 at the site of rs62066988 is associated with the increased risk of ALL in children.
