Analysis of the Risk Factors for Hemorrhagic Cystitis after Hematopoietic Stem Cell Transplantation.
10.19746/j.cnki.issn.1009-2137.2021.02.048
- Author:
Chun-Hong SUN
1
;
Xiao-Ning WANG
1
;
Min-Na LUO
1
;
Cai-Li GUO
1
;
Shi-Huan QI
1
;
Bei-Rong ZHANG
1
;
Fang WANG
1
;
Huan ZHANG
1
;
Peng-Cheng HE
2
Author Information
1. Department of Hematology，The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
2. Department of Hematology，The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China,E-mail: hepc@163.com.
- Publication Type:Journal Article
- MeSH:
Cystitis/etiology*;
Graft vs Host Disease;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Humans;
Retrospective Studies;
Risk Factors
- From:
Journal of Experimental Hematology
2021;29(2):610-614
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the risk factors affecting hemorrhagic cystitis(HC) after allogeneic hematopoietic stem cell transplantation(allo-HSCT).
METHODS:The clinical data of 153 patients underwent allogeneic hematopoietic stem cell transplantation in the First Affiliated Hospital of Xi'an Jiaotong University from January 2010 to December 2018 were selected and retrospectively analyzed. The incidence, median time and treatment outcome of HC should be observed. Multivariate analysis was used to observe the risk factors of HC in patients, including sex, age, diagnosis, disease status before transplantation, transplantation type, ATG and CTX in the pretreatment scheme, stem cell source, neutrophil and platelet implantation time; CMV, EBV and BKV infection, and acute graft-versus-host disease(aGVHD).
RESULTS:Among 153 patients underwent allogeneic hematopoietic stem cell transplantation, 25 (16.34%) patients had HC, the median occurance time was 31 days, all patients achieved complete remission after treatment, no bladder irritation and bladder contracture were left. The results of univariate and multivariate Logistic regression analysis showed that the type of transplantation, ATG, CMV viremia before treatment, aGVHD (r=1.036, 3.234, 3.298 and 2.817, respectively) were the independent risk factors of HC.
CONCLUSION:The urinary BKV detections in the patients with HC are positive, mainly occured during the period from day +13 to days +56. HLA haplotype, pretreatment including ATG, and CMV viremia, and aGVHD are the independent risk factors for HC after allo-HSCT.
