Expression and Clinical Significance of Heat Shock Protein 90 in Multiple Myeloma Patients.
10.19746/j.cnki.issn.1009-2137.2021.02.034
- Author:
Shun-Quan WU
1
;
Hui-Jun CHEN
1
;
Rong ZHAN
2
Author Information
1. Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, FUjian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China.
2. Fujian Insitute of Hematology, Fujian Provincial Key Laboratory of Hematology, FUjian Medical University Union Hospital, Fuzhou 350001, Fujian Province, China,E-mail: deanzhanrong@qq.com.cn.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
HSP90 Heat-Shock Proteins;
Humans;
Multiple Myeloma;
Prognosis;
beta 2-Microglobulin
- From:
Journal of Experimental Hematology
2021;29(2):525-529
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the expression of HSP90 in bone marrow samples of multiple myeloma (MM) patients and explore its clinical significance.
METHODS:Maxvision immunohistochemistry technique was used to detect the protein expression level of HSP90 76 MM patients and 29 normal healthy donors. The clinical characteristics of the patients were collected, and the correlation between the HSP90 expression and the clinical characteristics was analyzed.
RESULTS:The count of MM patients with positive HSP90 protein was significantly higher than that of normal healthy donor, and there were no significant correlation between HSP90 expression and age, sex, hemoglobin (Hb), creatinine (CREA), blood calcium, lactate dehydrogenase (LDH), bone marrow plasma cell proportion and MM subtypes (P>0.05), but HSP90 expression was correlated with β
CONCLUSION:HSP90 protein was over-expressed in MM patients, and was correlated with β
