A case of systemic lupus erythematosus presented with refractory serositis and nephritis during pregnancy.
- Author:
Hwi Ra PARK
1
;
Jung Soo SONG
;
Jane In SHIN
;
Bo Hyoung PARK
;
Won PARK
Author Information
1. Department of Internal Medicine, College of Medicine, Inha University, Incheon, Korea. parkwon@inha.ac.kr
- Publication Type:Case Report
- Keywords:
Systemic lupus erythematosus;
Serositis;
Lupus nephritis;
Pregnancy
- MeSH:
Abortion, Induced;
Antigen-Antibody Complex;
Autoantibodies;
Autoimmune Diseases;
Diagnosis;
Early Diagnosis;
Female;
Humans;
Immunoglobulins;
Leukopenia;
Lupus Erythematosus, Systemic*;
Lupus Nephritis;
Nephritis*;
Pericardial Effusion;
Pleural Effusion;
Pregnancy Trimester, Second;
Pregnancy*;
Proteinuria;
Raynaud Disease;
Serositis*;
Skin
- From:Korean Journal of Medicine
2004;67(Suppl 3):S896-S901
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibodies and immune complex depositions, has been known that it could be aggravated during pregnancy. We report a case who developed massive pericardial effusion, pleural effusion, and proteinuria during the second trimester of pregnancy. This patient had a history of leukopenia for several years and showed several features of SLE before pregnancy, however, no specific diagnosis was made before pregnancy. High dose oral glucocorticoid with intravenous immunoglobulin administration was done, but serositis and nephritis did not improve. The induced abortion and the use of immunosuppresive agent resulted in remission. We emphasize the importance of the early diagnosis and management of SLE before pregnancy in the patients with the features of autoimmune disease such as leukopenia, skin lesion and Raynaud phenomenon for successful outcome.
