Regulation Effect of Myeloid Leukemia No.1 Chinese Herb Medicine Prescription Combined with Chemotherapy on Th17 Cells in Bone Marrow of Patients with Acute Myeloid Leukemia.
10.19746/j.cnki.issn.1009-2137.2021.02.004
- Author:
Guo-Liang ZHANG
1
;
Ming PAN
2
;
Yan-Zhi WANG
3
;
Jian-Xia HUANG
1
;
Gang-Shou GU
1
;
Yan WANG
1
;
Qing WU
1
;
Li-Teng YAO
1
;
Huan-Rong XIE
1
;
Xing-Jiang HU
1
Author Information
1. Department of Hematology, Wuwei People's Hospital, Wuwei 733000, Gansu Province, China.
2. Department of Hematology, Wuwei People's Hospital, Wuwei 733000, Gansu Province, China,E-mail: 13893562119@163.com.
3. Department of Hematology, Gansu Wuwei Tumour Hospital, Wuwei 733000, Gansu Province, China.
- Publication Type:Journal Article
- MeSH:
Bone Marrow;
China;
Humans;
Leukemia, Myeloid, Acute/drug therapy*;
Medicine;
Prescriptions;
Th17 Cells;
Vascular Endothelial Growth Factor A
- From:
Journal of Experimental Hematology
2021;29(2):328-332
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the regulation effect of myeloid leukemia No.1 Chinese herb medicine prescription combined with chemotherapy on Th17 cells in bone marrow fluid of AML patients, so as to provide guidance for improving AML treatment effect and patients' long-term survival.
METHODS:Seventy patients with AML who were hospitalized in Department of Hematology, Wuwei People's Hospital from April 2017 to August 2019 were selected and enrolled in AML group, 25 healthy volunteers were selected and enrolled in control group; then according to therapeutic regimen, AML patients were divided into 2 groups: combined therapy group (myeloid leukemia NO.1 Chinese herb medicine prescription combined with chemotherapy) and non-combined therapy group (chemotherapy alone). Flow cytometry was used to detect the ratio of CD3
RESULTS:The ratio of CD3
CONCLUSION:Th17 cells expression in bone marrow of newly diagnoses and relapsed AML patients significantly increase, and decrease significantly after treatment. Myeloid leukemia No.1 Chinese herb prescription combined with chemotherapy can significantly increase the CR rate and reduce the RL rate for AML.
