Therapeutic Effect of PE+CRRT Combined with Chemotherapy on Children with Severe EBV-HLH and Non-EBV-HLH.
10.19746/j.cnki.issn.1009-2137.2021.01.043
- Author:
Yuan-Yuan LONG
1
;
Cheng-Shuang HUANG
1
;
Pei HUANG
2
;
Hong-Bo XU
1
;
Chuang XIE
1
;
Yan CHEN
3
Author Information
1. Department of Pediatrics, The Affiliated Hospital of Zunyi Medical University, Guizhou Children's Hospital, Zunyi 563000, Guizhou Province, China.
2. Department of Pediatrics, The Affiliated Hospital of Zunyi Medical University, Guizhou Children's Hospital, Zunyi 563000, Guizhou Province, China,E-mail: fenglin4620@163.com.
3. Department of Pediatrics, The Affiliated Hospital of Zunyi Medical University, Guizhou Children's Hospital, Zunyi 563000, Guizhou Province, China,E-mail: cyz600@163.com.
- Publication Type:Journal Article
- MeSH:
Child;
Continuous Renal Replacement Therapy;
Epstein-Barr Virus Infections/complications*;
Herpesvirus 4, Human;
Humans;
Lymphohistiocytosis, Hemophagocytic;
Plasma Exchange;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(1):259-264
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To investigate the difference in the therapeutic effect of plasma exchange and continuous renal replacement therapy (PE+CRRT) combined with chemotherapy in the treatment of children with severe Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis (EBV-HLH) and non-EBV-HLH.
METHODS:The clinical data of 21 cases of all children with severe HLH treated by PE+CRRT combined with chemotherapy from January 2017 to January 2020 were collected and retrospectively analyzed. According to the presence of EBV infection, the children were divided into EBV
RESULTS:Among the 21 children, 14 were divided into the EBV
CONCLUSION:PE+CRRT combined with chemotherapy can reduce serum ferritin quickly, then improve organ function, and increase the overall survival rate of severe HLH, and it is a good effect on children with severe EBV-HLH and non-EBV-HLH.
