Hepcidin and Erythroferrone Levels in Child-Bearing Women with Iron Deficiency Anemia.
10.19746/j.cnki.issn.1009-2137.2021.01.034
- Author:
Lian-Hong XU
1
;
Ying ZHANG
2
;
Yong WANG
2
;
Die HU
2
;
Jia-Hao XU
2
Author Information
1. Department of Clinical Laboratory Examination, The Wujin Hospital Affiliated to Jiangsu University,Changzhou 213017, Jiangsu Province, China ,Department of Clinical Laboratory Examination, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, Jiangsu Province, China,E-mail: xulh2104@163.com.
2. Department of Clinical Laboratory Examination, The Wujin Hospital Affiliated to Jiangsu University,Changzhou 213017, Jiangsu Province, China ,Department of Clinical Laboratory Examination, The Wujin Clinical College of Xuzhou Medical University, Changzhou 213017, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Anemia, Iron-Deficiency;
Child;
Enzyme-Linked Immunosorbent Assay;
Female;
Ferritins;
Hepcidins;
Humans;
Iron/metabolism*
- From:
Journal of Experimental Hematology
2021;29(1):213-216
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To detect serum hepcidin and erythroferrone levels in child-bearing women with iron deficiency anemia (IDA), and to investigate the association between them and iron status parameters.
METHODS:The study consisted of 65 child-bearing women (35 with iron deficiency anemia and 30 age-matched healthy women). The levels of serum iron were detected by using automated chemistry analyzer, the contents of serum ferritin were detected by electrochemiluminescence immunoassay, and the levels of serum erythroferrone and hepcidin were detected by specific enzyme-linked immunosorbent assay (ELISA) kit. The quantitative variables between two groups were compared and analyzed by SPSS22.0 software. Spearman correlation was used to detect correlation between the parameters.
RESULTS:The levels of Hb, serum iron, ferritin and transferrin saturation were significantly decreased in IDA patients as compared with in control group (P<0.001). Serum hepcidin levels in IDA patients were significant lower than those in control group (P<0.001). Serum erythroferrone levels slightly increased in IDA group (P>0.05). In IDA patients, serum hepcidin concentrations were positively correlated with hemoglobin concentration, serum iron, serum ferritin and transferrin saturation (r=0.448, r=0.496, r=0.754, r=0.491). But, serum erythroferrone concentrations showed no correlation with hemoglobin concentration, serum iron, serum ferritin, transferrin saturation and hepcidin (P>0.05).
CONCLUSION:Serum hepcidin levels were significantly decreased in child-bearing women with IDA, but the serum erythroferrone levels were not obviously different between two groups, suggesting that serum erythroferrone may be not involved in the regulation of iron metabolism in child-bearing women with mild and moderate IDA.
