Relationship between Changes of Lymphocyte Subsets and Early Hematologic Response in Immunosuppressive Therapy of Severe Aplastic Anemia Patients.
10.19746/j.cnki.issn.1009-2137.2021.01.033
- Author:
Yang LI
1
,
2
,
3
;
Guang-Xin PENG
4
;
Lei YE
4
;
Yuan LI
4
;
Jian-Ping LI
4
;
Hui-Hui FAN
4
;
Lin SONG
4
;
Wen-Rui YANG
4
;
Yang YANG
4
;
Kang ZHOU
4
;
Li ZHANG
4
;
Li-Ping JING
4
;
Xin ZHAO
4
;
Feng-Kui ZHANG
5
Author Information
1. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology &
2. Blood Disease Hospital, Chinese Academy of Medical Sciences &
3. Peking Union Medical College, Tianjin 300020, China.
4. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China.
5. State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Disease Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China,E-mail: fkzhang@ihcams.ac.cn.
- Publication Type:Journal Article
- MeSH:
Anemia, Aplastic;
Humans;
Immunosuppression;
Immunosuppressive Agents/therapeutic use*;
Lymphocyte Subsets;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(1):207-212
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the relationship between the change of lymphocyte subsets before and after immunosuppressive therapy (IST) with disease severity of severe aplastic anemia (SAA) and hematologic response to IST.
METHODS:The clinical data of 94 patients with SAA/VSAA treated by r-ATG and CsA in our hospital from December 2009 to October 2011 was analyzed retrospectively. Among them, 26 patients who had sequential data of lymphocyte subsets and cytokines before and after treatment were enrolled. The relationship between lymphocyte subsets, cytokine level before IST and disease severity, as well as the relationship between changes if lymphocyte subsets, changes of cytokine and the HR after IST for 6 months was analyzed.
RESULTS:There were no statistical differences in the ratio and absolute count of lymphocyte, the ratio and absolute count of each lymphocyte subsets, including CD3
CONCLUSION:The hematopoietic recovery and early hematologic remission may be affected by the intensity of immune suppression reflected from the changes of lymphocyte subsets and the immune reconstruction reflected from the recovery of lymphocyte subsets. The immune reconstruction is most significant within 3 months after IST.
