Prognostic Value of R-ISS Staging Combined with "Multiple-Hits" in Patients with Multiple Myeloma.
10.19746/j.cnki.issn.1009-2137.2021.01.025
- Author:
Hui-Min SUN
1
;
Shun-Sheng ZHAI
2
;
Yan LI
3
Author Information
1. Medical School of Shihezi University, Shihezi 832001, Xinjiang Uygur Autonomous Region, China.
2. Department of Haematology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China.
3. Department of Haematology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, Xinjiang Uygur Autonomous Region, China,E-mail:liyan232917@139.com.
- Publication Type:Journal Article
- MeSH:
Chromosome Aberrations;
Humans;
Multiple Myeloma/pathology*;
Neoplasm Staging;
Prognosis;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(1):158-166
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the prognostic value of R-ISS staging combined with "Multiple-Hits" in patients with multiple myeloma (MM), and to detected the effect of different "Multiple- Hits" combinations to the prognosis of the patients.
METHODS:The 220 MM patients treated in the hematology department of People's Hospital of Xinjiang Uygur Autonomous Region from April 2013 to October 2019 were enrolled and retrospective analyzed. All the patients were detected by FISH. The effects of R-ISS staging combined with "Multiple-Hits" and different "Multiple-Hits" combinations to the prognosis of the patients were compared.
RESULTS:For the patients at R-ISS stage II and III, the median progression-free survival (PFS) time, overall survival (OS) time and duration of response (DOR) time in "Multiple-Hits" patients were all shorter than those without high-risk cytogenetic abnormality (HRCA) and those with only one type of HRCA (P<0.05), while the TTR (time to response) was significantly prolonged (P<0.05). For the prognosis of the patients among the three different "Multiple-Hits" combinations(1q21+ combined with del(17p), 1q21+ combined with t(14;16) and combined 1q21+ combined with t(4;14)), 1q21+ combined with del(17p) showed the worst prognosis.
CONCLUSION:The patients with Different "Multiple-Hits" combinations shows different prognosis. The R-ISS staging combination with "Multiple-Hits" is more conducive to accurately judging the prognosis of MM patients.
