Analysis on Related Factors of Pulmonary Infection in Patients with Multiple Myeloma Treated with Bortezomib.
10.19746/j.cnki.issn.1009-2137.2021.01.024
- Author:
Gao LI
1
;
Qi-Ke ZHANG
1
;
Xiao-Fang WEI
1
;
You-Fan FENG
1
;
Wen-Hui YANG
1
;
Yan-Qing SUN
2
Author Information
1. Department of Hematology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.
2. Department of Hematology, Gansu Provincial Hospital, Lanzhou 730000, Gansu Province, China.E-mail: 491049515@qq.com.
- Publication Type:Journal Article
- MeSH:
Bortezomib;
Drug Resistance, Bacterial;
Humans;
Microbial Sensitivity Tests;
Multiple Myeloma/drug therapy*;
Retrospective Studies
- From:
Journal of Experimental Hematology
2021;29(1):152-157
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To analyze the risk factors, distribution of pathogenic strains and tolerance of pulmonary infection in patients with multiple myeloma(MM) during bortezomib chemotherapy.
METHODS:The clinical data of 85 patients with multiple myeloma treated by bortezomib in our hospital from January 2015 to January 2019 was analyzed. The patients were divided into infection group and control group according to whether they were infected. The tolerance, pathogen distribution, and related risk factors were retrospectively analyzed.
RESULTS:Pulmonary infection rate was 55.29% in 85 MM patients. The proportions of the patients with anemia, neutropenia, and ECOG score ≥2 points in the infection group were significantly higher than those in the control group (P<0.05). In this study, 30 strains of pathogenic bacteria were detected, with gram-negative bacteria accounting for 60%, gram-positive bacteria for 33.33%, fungi for 3.3% and tuberculosis bacteria for 3.3%. Pseudomonas aeruginosa, klebsiella pneumoniae, streptococcus pneumoniae, staphylococcus aureus accounted showed the highest proportion. Most of MM patients with pulmonary infection showed a heterprognosis after two weeks antibiotic treatment, while 3 patients died. About 30 percent of early deaths were due to pulmonary infections.
CONCLUSION:Anemia, neutropenia, ECOG score ≥2 points are the major clinical characteristics of the multiple myeloma patients with pulmonary infections. Pulmonary infection is an important cause of early death in patients with multiple myeloma. Pathogenic bacteria are mainly composed of gram-negative bacteria. Beta-lacta/ beta-lactamase inhibitor combinations or Carbapenems are effective empiric treatment for controlling the progression of pulmonary infection.
